Table I.

Outline and design per trial.

Study	Year	Country	Number of participants	Intervention*			Cancellation criteria	Outcomes
				Clomiphene citrate	Letrozole	Gonadotrophins
Danhof et al.	2018	The Netherlands	738	100 mg		75 IU	Max 3 follicles of ≥ 14 mm or max 5 follicles of ≥ 12 mm	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception, cancellation, number of follicles
Dankert et al.	2007	The Netherlands	138	100 mg		75 IU	Max 3 follicles of ≥ 14 mm	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception
Diamond et al.	2015	USA	900	100 mg	5 mg	150 IU	Max 4 follicles (mean diameter >18 mm) or max serum E2 levels of 3000 pg/ml	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception, cancellation, number of follicles
Ecochard et al.	2000	France	54	50 or 100 mg		150 IU	Max 3 follicles of ≥ 15 mm and/or max serum E2 levels of 1200 pg/ml	Clinical pregnancy, miscarriage
Erdem et al.	2015	Turkey	219	100 mg		75 IU	Max 4 follicles of ≥ 14 mm and/or max serum E2 levels of 1500 pg/ml	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception, cancellation, number of follicles
Naidu et al.	2020	India	112	100 mg		75 IU	Max 3 follicles of ≥ 18 mm‡	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception, cancellation, number of follicles
Peeraer et al.	2015	Belgium	250	50 mg		37.5 or 75 IU	Max 3 follicles of ≥ 14 mm	Live birth, multiple pregnancy, clinical pregnancy, ongoing pregnancy, miscarriage, time to conception, cancellation, number of follicles

^*Start dosing, during the cycles dosage can be adjusted. ^‡No participants had more than three dominant (≥14 mm) follicles in the trial.