Table V.
Sensitivity analyses on live birth and multiple pregnancy comparing gonadotrophins versus clomiphene citrate.
| Sensitivity analysis | Outcome | Number of RCTs | Number of participants | Risk Ratio (RR) | 95% CI | I 2 |
|---|---|---|---|---|---|---|
| RCTs with low risk of bias at allocation concealment* | Live birth | 5 | 1839 | 1.23 | 1.05–1.45 | 0% |
| Multiple pregnancy | 5 | 1839 | 2.37 | 1.39–4.04 | 78% | |
|
| ||||||
| RCTs with low starting dose of gonadotrophins (≤75IU)** | Live birth | 5 | 1457 | 1.26 | 1.05–1.51 | 37% |
| Multiple pregnancy | 5 | 1457 | 0.94 | 0.45–1.96 | 0% | |
|
| ||||||
| RCTs with stricter cancellation criteria (≤ 3 dominant follicles)*** | Live birth | 4 | 1238 | 1.15 | 0.94–1.41 | 0% |
| Multiple pregnancy | 4 | 1238 | 0.81 | 0.32–2.03 | 0% | |
*
Erdem (2015) was excluded;
**
Diamond (2015) was excluded;
***
Both Erdem (2015) and Diamond (2015) were excluded.
RCT, randomized controlled trial.