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. 2022 Aug 18;12:939994. doi: 10.3389/fonc.2022.939994

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Copyright © 2022 Tan, Zeng, Li, Tan and Zhu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circ0038632 silencing suppresses the function of proliferation and metastasis in osteosarcoma. (A) siRNAs were used to knockdown circ0038632 expression in osteosarcoma cells. (B) Cell proliferation ability was evaluated through CCK-8 assay. (C) BrdUrd incorporation was assessed by immunohistochemistry (IHC) to evaluate cell proliferation after transfection. (D) Statistical chart of BrdUrd total gray value. (E) The pictures of clone formation from osteosarcoma cells were showed. (F) Statistical chart of cloning derived from osteosarcoma cells. (G) Migration ability was assessed by wound healing assay. (H) Statistical chart of wound closure. (I) Mouse xenograft models were established to evaluate circ0038632 intravital function. (J) Statistical chart of tumor weights. (K) The pictures of lung metastatic nodules with HE staining were showed. (L) Statistical chart of metastatic nodules. *P < 0.05 and **P < 0.01.