Table 1.
Baseline Sociodemographic, MRI, and Cognitive Data by Baseline Frailty Status
| Entire Sample | Low Frailty (0.26) | High Frailty (0.26) | |
|---|---|---|---|
| n = 385 | n = 259 | n = 126 | |
| Age (mean in years, SD) | 72.5 (7.0) | 70.9 (6.4) | 75.8 (7.2) |
| Female sex (n, %) | 171 (44.4%) | 109 (42%) | 62 (49.2%) |
| Level of education (mean in years, SD) | 10.9 (3.6) | 11.2 (3.8) | 10.3 (3.2) |
| Frailty index (%, median, IQR) | 0.21 (0.14, 0.29) | 0.16 (0.11, 0.21) | 0.33 (0.29, 0.39) |
| MRI measures | |||
| Total cSVD (median, IQR) | 1 (0, 2) | 1 (0, 2) | 2 (1, 2) |
| cSVD by strata (n, %) | |||
| 0 | 126 (32.7%) | 103 (39.8%) | 23 (18.3%) |
| 1 | 130 (33.8%) | 91 (35.1%) | 39 (31.0%) |
| 2 | 84 (21.8%) | 48 (18.5%) | 36 (28.6%) |
| 3 | 29 (7.5%) | 13 (5.0%) | 16 (12.7%) |
| 4 | 16 (4.2%) | 4 (1.5%) | 12 (9.5%) |
| WMH (n, %) | |||
| Periventricular = 3 | 72 (18.7%) | 33 (12.7%) | 39 (31%) |
| Deep ≥ 2 | 96 (24.9%) | 48 (18.5%) | 48 (38.1%) |
| SI (n, %) | 71 (18.4%) | 35 (13.5%) | 36 (28.6%) |
| CMB (n, %) | 30 (7.8%) | 12 (4.6%) | 18 (14.3%) |
| EPVS >20 (n, %) | 229 (59.5%) | 136 (52.5%) | 93 (73.8%) |
| GMV (mL, median, IQR) | 540 (502, 575) | 550 (508, 585) | 519 (487, 557) |
| TIV (mL, median, IQR) | 1 435 (1 323, 1 520) | 1 441 (1 331, 1 535) | 1 421 (1 308, 1 497) |
| Cognitive function (z scores) | |||
| Global cognition (mean, SD) | 0.21 (0.88) | −0.47 (1.09) | |
| Processing speed (mean, SD) | 0.26 (0.85) | −0.54 (1.07) | |
| Visuospatial ability (mean, SD) | 0.20 (0.78) | −0.42 (1.25) | |
| Executive function (mean, SD) | 0.17 (0.59) | −0.36 (1.49) | |
| Verbal fluency (mean, SD) | 0.13 (0.92) | −0.27 (1.10) | |
| Working memory (mean, SD) | 0.13 (0.99) | −0.26 (0.98) | |
| Verbal memory (mean, SD) | 0.14 (0.94) | −0.28 (1.07) | |
| Visual memory (mean, SD) | 0.16 (0.99) | −0.33 (0.94) |
Notes: CMB = cerebral microbleeds; cSVD = cerebral small vessel disease; EPVS = enlarged perivascular spaces; GMV = gray matter volume; IQR = interquartile range; MRI = magnetic resonance imaging; SD = standard deviation; SI = subcortical infarcts; TIV = total intracranial volume; WMH = white matter hyperintensities, presented as n (%) above threshold as rated by Modified Fazekas Scale.