Table 3.
Associations Between MRI Measures and Cognitive Domains Over Time Stratified by Baseline Frailty Status, Adjusting for Age, Sex, and Years of Formal Education and Additionally Adjusting for Total Intracranial Volume in Gray Matter Models
| Low Frailty (FI < 0.26) | High Frailty (FI > 0.26) | |||||
|---|---|---|---|---|---|---|
| Beta | 95% CI | p Value | Beta | 95% CI | p Value | |
| cSVD (n) | ||||||
| Global cognition | ||||||
| Time | 0.010 | −0.014, 0.034 | .41 | −0.041 | −0.090, 0.009 | .11 |
| cSVD | −0.038 | −0.136, 0.061 | .45 | −0.001 | −0.178, 0.177 | .99 |
| cSVD × time | −0.017 | −0.033, −0.002 | .03 | −0.014 | −0.037, 0.008 | .21 |
| GMV (mL) | ||||||
| Global cognition | ||||||
| Time | −0.100 | −0.248, 0.050 | .19 | −0.066 | −0.267, 0.135 | .52 |
| GMV | 0.005 | 0.001, 0.008 | .009 | 0.007 | 0.001, 0.013 | .03 |
| GMV × time | 0.0002 | −0.0001, 0.0004 | .28 | −0.0001 | −0.0004, 0.0004 | .94 |
Notes: cSVD = cerebral small vessel disease; 95% CI = 95% confidence intervals; FI = frailty index; GMV = gray matter volume; MRI = magnetic resonance imaging.