Table 3.
The results of the full factorial analysis of covariance (ANCOVA) on the total cortical surface area (SA) in the whole sample of patients with schizophrenia (SCZ) spectrum disorders and healthy controls (HC) are presented
| F | P value | |
|---|---|---|
| Whole sample (n = 329) | ||
| CMV status (CMV−/CMV+) | 13.077 | <.001 |
| Diagnostic group (SCZ/HC) | 6.397 | .012 |
| Sex | 63.095 | <.001 |
| CMV status-by-diagnostic group-by-sex | 0.157 | .692 |
| CMV status-by-diagnostic group | 5.482 | .020 |
| CMV status-by-sex | 0.174 | .677 |
| Diagnostic group-by-sex | 3.646 | .057 |
| Age | 4.948 | .027 |
| SCZ spectrum (n = 67) | ||
| CMV status | 10.091 | .002 |
| Sex | 6.892 | .011 |
| Duration of illness | 5.248 | .025 |
| HC (n = 262) | ||
| CMV status | 3.600 | .059 |
| Sex | 131.667 | <.001 |
| Age | 2.035 | .155 |
Note: There was a significant cytomegalovirus (CMV) status-by-diagnostic group interaction which we followed up stratifying by diagnostic group (we ran an ANCOVA among patients and an ANCOVA among HC). CMV seropositive (CMV+) patients had smaller SA than CMV seronegative (CMV−) patients, whereas CMV+ and CMV- HC did not significantly differ in SA. The selection of covariates in the three ANCOVAs was based on the bivariate analyses.