Table 1.
RRHO-Z Scores for the Shared Genetic Components between Major Psychiatric Disorders and Cortical Structures, and Factor Scores for the Two Latent Factors Identified by the Main Exploratory Factor Analysis
| Cortical Traits | RRHO-Z Scores | Latent Factors | |||||
|---|---|---|---|---|---|---|---|
| ADHD | ASD | BD | MDD | SCZ | F1 | F2 | |
| Cortical surface area | |||||||
| Total surface area | 11.29 | 16.15 | 13.88 | 12.41 | 17.94 | 2.30 | 1.81 |
| Banks of the superior temporal sulcus | 6.39 | 4.42 | 7.61 | 7.04 | 8.17 | −0.42 | −1.00 |
| Caudal anterior cingulate | 8.39 | 15.67 | 8.65 | 7.94 | 8.03 | −0.24 | 1.35 |
| Caudal middle frontal | 4.35 | 5.21 | 8.45 | 9.87 | 8.24 | 0.01 | −1.44 |
| Cuneus | 13.46 | 5.82 | 10.31 | 9.66 | 13.25 | 1.26 | 0.38 |
| Entorhinal | 9.58 | 5.96 | 6.97 | 5.88 | 9.62 | −0.37 | −0.03 |
| Frontal pole | 9.10 | 11.80 | 4.32 | 3.58 | 6.41 | −1.54 | 1.09 |
| Fusiform | 7.33 | 15.10 | 7.02 | 4.81 | 12.28 | −0.58 | 1.44 |
| Inferior parietal | 6.93 | 8.71 | 14.12 | 5.89 | 12.46 | 0.59 | 0.07 |
| Inferior temporal | 5.82 | 4.98 | 7.97 | 4.37 | 8.77 | −0.79 | −0.76 |
| Insula | 11.34 | 8.73 | 11.71 | 10.88 | 15.04 | 1.63 | 0.50 |
| Isthmus cingulate | 7.53 | 9.91 | 7.14 | 4.97 | 9.12 | −0.75 | 0.41 |
| Lateral occipital | 9.30 | 12.58 | 10.39 | 8.24 | 14.98 | 0.84 | 1.08 |
| Lateral orbitofrontal | 9.21 | 15.40 | 10.83 | 10.09 | 11.96 | 0.83 | 1.36 |
| Lingual | 7.08 | 9.34 | 5.85 | 6.75 | 10.99 | −0.45 | 0.14 |
| Medial orbitofrontal | 11.59 | 9.47 | 12.01 | 8.82 | 14.41 | 1.27 | 0.83 |
| Middle temporal | 8.24 | 10.27 | 9.79 | 8.66 | 12.55 | 0.56 | 0.38 |
| Paracentral | 5.73 | 4.82 | 5.73 | 8.76 | 8.99 | −0.35 | −1.15 |
| Parahippocampal | 6.81 | 4.97 | 6.57 | 7.99 | 7.10 | −0.49 | −0.93 |
| Pars opercularis | 5.51 | 4.65 | 6.19 | 5.65 | 5.89 | −1.11 | −1.05 |
| Pars orbitalis | 4.67 | 11.70 | 4.24 | 6.62 | 4.79 | −1.49 | 0.02 |
| Pars triangularis | 4.46 | 3.10 | 5.51 | 6.30 | 10.07 | −0.71 | −1.45 |
| Pericalcarine | 9.98 | 6.82 | 11.75 | 11.76 | 15.58 | 1.78 | −0.15 |
| Postcentral | 6.50 | 7.39 | 8.08 | 7.11 | 9.64 | −0.25 | −0.40 |
| Posterior cingulate | 8.56 | 8.57 | 13.61 | 13.61 | 12.49 | 1.89 | −0.31 |
| Precentral | 5.38 | 3.59 | 7.54 | 8.03 | 7.58 | −0.38 | −1.42 |
| Precuneus | 4.63 | 4.87 | 10.30 | 7.21 | 12.04 | 0.21 | −1.14 |
| Rostral anterior cingulate | 6.25 | 5.27 | 8.65 | 10.01 | 9.14 | 0.26 | −1.09 |
| Rostral middle frontal | 5.92 | 7.23 | 6.82 | 6.44 | 11.42 | −0.37 | −0.42 |
| Superior frontal | 7.74 | 13.44 | 5.84 | 5.56 | 9.36 | −0.84 | 1.07 |
| Superior parietal | 6.33 | 5.86 | 9.09 | 6.14 | 10.44 | −0.18 | −0.62 |
| Superior temporal | 7.43 | 20.75 | 12.03 | 12.33 | 10.48 | 0.99 | 1.82 |
| Supramarginal | 9.52 | 5.00 | 7.32 | 7.37 | 7.40 | −0.30 | −0.40 |
| Temporal pole | 4.45 | 4.49 | 8.13 | 6.91 | 8.90 | −0.43 | −1.29 |
| Transverse temporal | 9.71 | 19.24 | 11.73 | 8.72 | 15.54 | 1.04 | 2.36 |
| Cortical thickness | |||||||
| Average thickness | 8.44 | 14.02 | 18.89 | 15.35 | 20.35 | 3.51 | 0.72 |
| Banks of the superior temporal sulcus | 8.09 | 6.35 | 9.49 | 10.11 | 9.22 | 0.48 | −0.58 |
| Caudal anterior cingulate | 10.82 | 9.28 | 7.22 | 6.65 | 12.13 | 0.05 | 0.80 |
| Caudal middle frontal | 5.44 | 11.68 | 7.39 | 6.87 | 11.91 | −0.29 | 0.30 |
| Cuneus | 4.48 | 4.20 | 6.85 | 6.22 | 8.47 | −0.73 | −1.29 |
| Entorhinal | 6.56 | 6.37 | 8.60 | 6.91 | 9.66 | −0.19 | −0.56 |
| Frontal pole | 6.09 | 12.28 | 5.90 | 4.57 | 7.55 | −1.26 | 0.60 |
| Fusiform | 4.78 | 9.74 | 7.19 | 6.58 | 6.33 | −0.93 | −0.30 |
| Inferior parietal | 7.22 | 12.20 | 8.37 | 6.98 | 11.37 | −0.11 | 0.67 |
| Inferior temporal | 9.96 | 15.63 | 11.22 | 6.27 | 11.69 | 0.27 | 1.83 |
| Insula | 8.04 | 9.39 | 9.91 | 8.14 | 8.38 | 0.08 | 0.11 |
| Isthmus cingulate | 7.38 | 3.99 | 10.79 | 8.31 | 12.00 | 0.64 | −0.93 |
| Lateral occipital | 6.18 | 12.51 | 8.10 | 8.43 | 9.14 | −0.20 | 0.38 |
| Lateral orbitofrontal | 6.24 | 9.10 | 6.96 | 10.63 | 8.26 | −0.01 | −0.44 |
| Lingual | 3.46 | 5.11 | 4.33 | 6.88 | 6.19 | −1.25 | −1.40 |
| Medial orbitofrontal | 7.14 | 13.16 | 9.76 | 9.57 | 11.07 | 0.44 | 0.61 |
| Middle temporal | 6.49 | 11.68 | 7.38 | 5.57 | 10.05 | −0.63 | 0.54 |
| Paracentral | 8.33 | 12.28 | 11.20 | 8.33 | 12.23 | 0.62 | 0.78 |
| Parahippocampal | 8.20 | 8.28 | 9.07 | 8.77 | 11.31 | 0.40 | −0.04 |
| Pars opercularis | 4.83 | 4.33 | 9.16 | 10.71 | 14.59 | 0.92 | −1.42 |
| Pars orbitalis | 4.78 | 7.69 | 3.41 | 5.15 | 4.96 | −1.74 | −0.58 |
| Pars triangularis | 3.11 | 5.74 | 4.82 | 5.03 | 7.30 | −1.41 | −1.16 |
| Pericalcarine | 8.56 | 5.78 | 5.41 | 7.15 | 7.74 | −0.61 | −0.38 |
| Postcentral | 10.50 | 10.84 | 13.16 | 11.35 | 15.33 | 1.83 | 0.71 |
| Posterior cingulate | 8.46 | 4.46 | 8.38 | 6.83 | 7.70 | −0.28 | −0.63 |
| Precentral | 4.52 | 8.59 | 11.13 | 7.69 | 10.20 | 0.14 | −0.56 |
| Precuneus | 4.54 | 4.71 | 3.72 | 3.80 | 5.19 | −1.85 | −1.06 |
| Rostral anterior cingulate | 5.66 | 14.01 | 8.43 | 7.85 | 10.27 | −0.20 | 0.64 |
| Rostral middle frontal | 4.44 | 11.68 | 6.42 | 5.53 | 7.99 | −1.09 | 0.14 |
| Superior frontal | 6.66 | 5.16 | 6.74 | 7.85 | 9.69 | −0.24 | −0.84 |
| Superior parietal | 5.06 | 5.53 | 7.76 | 6.75 | 4.50 | −0.92 | −1.09 |
| Superior temporal | 12.02 | 16.21 | 9.81 | 9.05 | 12.92 | 0.79 | 2.11 |
| Supramarginal | 8.10 | 15.63 | 12.33 | 9.13 | 11.81 | 0.77 | 1.28 |
| Temporal pole | 4.69 | 3.81 | 7.14 | 5.00 | 7.26 | −1.00 | −1.26 |
| Transverse temporal | 7.96 | 16.46 | 10.13 | 10.67 | 10.43 | 0.58 | 1.26 |