Table 1.
The regulation of lactylation in cell lines and diseases
| Cell lines | Lactylated protein(s)/site(s) | Function and mechanism | Disease |
|---|---|---|---|
| MCF-7 | H3K9,18,23,27,56,122 | N/A | Breast cancer16 |
| H4K5,8,12,31,77,91 | |||
| HeLa | H3K9,18,23,27,79 | N/A | Cervical cancer16 |
| H4K5,8,12,16,31,77,91 | |||
| H2AK11,13,115 | |||
| H2BK5,11,15,16,20,23,43,85,108,116,120 | |||
| MEF | N/A | N/A | N/A |
| HCT116 | H3K18 | N/A | Colon cancer16 |
| BMDM | H3K14,18,23,27,56 | Wound healing 16; inflammation repair 70; tumor cell proliferation; pulmonary fibrosis 72; upregulate ARG1, PDGFA, THBS1, and VEGFA. | N/A |
| H4K8,12,31,91 | |||
| H2AK11,115 | |||
| H2BK5,11,15,16,20,85,108 | |||
| HepG2 | H3K18 | N/A | Hepatocellular carcinoma16 |
| HEK293T | H3K18 | N/A | N/A |
| LLC1 | H3K18 | N/A | Lung cancer 16 |
| B16F10 | H3K18 | N/A | Cutaneous melanoma16 |
| PIG1 | H3K18 | N/A | N/A |
| OCM1/OMM1/MUM2B/CRMM1/2/CM2005.1 | H3K18 | Tumorigenesis 74; upregulate the oncogene YTHDF2. | Ocular melanoma74 |
| BEAS-2B/A549/H1299 | H4 | Tumor cell proliferation 76; upregulate SDH and IDH; downregulate HK-1 and PKM. | Non-small cell lung cancer76 |
Notes: N/A not available