Table 3.
Two-factor additive interaction between amino acids and Metformin.
| OR (95% CI) | P value | |
|---|---|---|
| Additive interaction model of Glu and Metformin | ||
| Glu<98 and No-Metformin | Reference | |
| Glu<98 and Metformin | 0.67 (0.38, 1.18) | 0.159 |
| Glu≥98 and No-Metformin | 0.44 (0.27, 0.71) | < 0.001 |
| Glu≥98 and Metformin | 0.61 (0.33, 1.13) | 0.108 |
| RERI | 0.431 (0.077, 0.784) | |
| APAB | 0.262 (0.104, 0.420) | |
| S | 2.996 (0.693, 12.962) | |
| Additive interaction model of Gly and Metformin | ||
| Gly<196 and No-Metformin | Reference | |
| Gly<196 and Metformin | 0.77 (0.47, 1.27) | 0.299 |
| Gly≥196 and No-Metformin | 0.46 (0.29, 0.75) | 0.001 |
| Gly≥196and Metformin | 0.57 (0.34, 0.98) | 0.036 |
| RERI | 0.463 (0.102, 0.824) | |
| APAB | 0.275 (0.119, 0.432) | |
| S | 3.101 (0.695, 13.824) | |
| Additive interaction model of Leu and Metformin | ||
| Leu<128 and No-Metformin | Reference | |
| Leu <128 and Metformin | 0.85 (0.54, 1.34) | 0.485 |
| Leu≥128 and No-Metformin | 0.48 (0.29, 0.8) | 0.004 |
| Leu≥128 and Metformin | 0.71 (0.44, 1.15) | 0.153 |
| RERI | 0.376 (0.0753, 0.676) | |
| APAB | 0.263 (0.102, 0.424) | |
| S | 8.168 (0.005, 12833.36) | |
| Additive interaction model of His and Metformin | ||
| His<51 and No-Metformin | Reference | |
| His <51 and Metformin | 0.88 (0.56, 1.37) | 0.559 |
| His≥51 and No-Metformin | 0.46 (0.29, 0.75) | 0.001 |
| His≥51 and Metformin | 0.73 (0.45, 1.17) | 0.181 |
| RERI | 0.458 (0.097, 0.818) | |
| APAB | 0.273 (0.118, 0.429) | |
| S | 3.100 (0.707, 13.580) | |
| Additive interaction model of Phe and Metformin | ||
| Phe<47 and No-Metformin | Reference | |
| Phe <47 and Metformin | 0.83 (0.54, 1.3) | 0.418 |
| Phe≥47 and No-Metformin | 0.24 (0.14, 0.42) | < 0.001 |
| Phe≥47and Metformin | 0.72 (0.46, 1.15) | 0.166 |
| RERI | 0.427 (0.090, 0.764) | |
| APAB | 0.275 (0.117, 0.432) | |
| S | 4.377 (0.294, 65.066) | |
| Additive interaction model of Tyr and Metformin | ||
| Tyr<47 and No-Metformin | Reference | |
| Tyr <47 and Metformin | 0.81 (0.53, 1.26) | 0.351 |
| Tyr≥47 and No-Metformin | 0.41 (0.24, 0.68) | < 0.001 |
| Tyr≥47 and Metformin | 0.71 (0.45, 1.12) | 0.138 |
| RERI | 0.384 (0.067, 0.701) | |
| APAB | 0.256 (0.094, 0.418) | |
| S | 4.328 (0.213, 87.960) | |
Glu Glutamate, Gly Glycine, Leu Leucine, His Histidine, Phe Phenylalanine, Tyr tyrosine, OR odds ratio, CI confidence interval, RERI risk due to interaction, AP attributable proportion due to interaction, S synergy index.
Multivariable Model was adjusted for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, glycosylated hemoglobin, uric acid, serum creatinine.
Significant elative excess risk due to two of interaction (RERI) > 0, attributable proportion due to interaction (AP) > 0 or synergy index (S) > 1 indicates a significant additive interact.