Table 3.
Receiver operating characteristics (ROC) curves and prognostic accuracy of blood cell count-derived inflammation indexes in non-elderly and elderly COVID-19.
| Variables | AUC | 95% CI | p-value | Cut-off | Sensitivity | Specificity (%) |
|---|---|---|---|---|---|---|
| WBC | ||||||
| Non-elderly | 0.976 | 0.965–0.984 | 0.000 | >8.94 | 93.3 | 96 |
| Elderly | 0.942 | 0.923–0.958 | 0.000 | >9.12 | 85.8 | 94.3 |
| All | 0.969 | 0.960–0.977 | 0.000 | >9.05 | 88.95 | 95.90 |
| P1 | 0.013 | |||||
| Neutrophil | ||||||
| Non-elderly | 0.981 | 0.971–0.988 | 0.000 | >8.91 | 91.9 | 97.8 |
| Elderly | 0.943 | 0.924–0.959 | 0.000 | >8.93 | 86.7 | 91.7 |
| All | 0.971 | 0.962–0.978 | 0.000 | >8.79 | 89.8 | 94.3 |
| P1 | 0.003 | |||||
| Lymphocyte | ||||||
| Non-elderly | 0.578 | 0.548–0.608 | 0.003 | <1.02 | 65.9 | 53.1 |
| Elderly | 0.551 | 0.513–0.588 | 0.036 | <0.64 | 30.7 | 81.3 |
| All | 0.566 | 0.543–0.589 | 0.000 | <0.91 | 50.4 | 61.2 |
| P1 | 0.443 | |||||
| NLR | ||||||
| Non-elderly | 0.839 | 0.815–0.860 | 0.000 | >9.38 | 73.3 | 86.5 |
| Elderly | 0.785 | 0.753–0.814 | 0.000 | >9.13 | 70.2 | 78.3 |
| All | 0.817 | 0.798–0.835 | 0.000 | >9.21 | 71.39 | 83.1 |
| P1 | 0.061 | |||||
| MLR | ||||||
| Non-elderly | 0.644 | 0.615–0.673 | 0.000 | >0.26 | 65.9 | 64.9 |
| Elderly | 0.603 | 0.566–0.639 | 0.000 | >0.36 | 38.5 | 80.5 |
| All | 0.628 | 0.605–0.651 | 0.000 | >0.26 | 59.4 | 62.4 |
| P1 | 0.238 | |||||
| PLR | ||||||
| Non-elderly | 0.603 | 0.573–0.632 | 0.000 | >0.22 | 62.2 | 60.8 |
| Elderly | 0.575 | 0.537–0.612 | 0.002 | >0.27 | 39.4 | 75.9 |
| All | 0.585 | 0.562–0.608 | 0.000 | >0.23 | 52.6 | 63.1 |
| P1 | 0.434 | |||||
| SIR-I | ||||||
| Non-elderly | 0.864 | 0.842–0.884 | 0.000 | >2.46 | 73.3 | 90.2 |
| Elderly | 0.813 | 0.783–0.841 | 0.000 | >2.32 | 71.6 | 80.9 |
| All | 0.845 | 0.827–0.862 | 0.000 | >2.32 | 72.8 | 85.7 |
| P1 | 0.061 | |||||
| SII | ||||||
| Non-elderly | 0.848 | 0.825–0.869 | 0.000 | >1,994 | 74.1 | 87.2 |
| Elderly | 0.800 | 0.769–0.829 | 0.000 | >1,868 | 70.2 | 80.4 |
| All | 0.826 | 0.807–0.843 | 0.000 | >1,928 | 71.1 | 84.3 |
| P1 | 0.091 | |||||
| dNLR | ||||||
| Non-elderly | 0.900 | 0.880–0.917 | 0.000 | <5.90 | 90.4 | 97.6 |
| Elderly | 0.821 | 0.791–0.848 | 0.000 | <5.83 | 82.6 | 92.9 |
| All | 0.854 | 0.837–0.871 | 0.000 | <5.83 | 85.5 | 95.9 |
| P1 | 0.011 | |||||
| NLPR | ||||||
| Non-elderly | 0.828 | 0.804–0.850 | 0.000 | >0.044 | 72.6 | 85.7 |
| Elderly | 0.770 | 0.737–0.801 | 0.000 | >0.045 | 69.3 | 76.9 |
| All | 0.807 | 0.788–0.825 | 0.000 | >0.044 | 71.1 | 82.3 |
| P1 | 0.048 | |||||
| AISI | ||||||
| Non-elderly | 0.871 | 0.849–0.890 | 0.000 | >492 | 76.3 | 89.1 |
| Elderly | 0.826 | 0.796–0.853 | 0.009 | >518 | 69.3 | 86.5 |
| All | 0.852 | 0.835–0.868 | 0.000 | >517 | 71.1 | 89 |
| P1 | 0.090 | |||||
AISI, aggregate index of systemic inflammation; dNLR, derived neutrophil/lymphocyte ratio; MLR, monocyte/lymphocyte ratio; NLPR, neutrophil/lymphocyte*platelet ratio; NLR, neutrophil/lymphocyte ratio; PLR, platelet/lymphocyte ratio; SII, systemic inflammation index; SIR-I, systemic inflammation response index; WBC, white blood cell. P1, P-value of non-elderly vs. elderly patients.