Table 1.
Heart Weight and Vessel Sizes
| WT Pigs | GHRKO Pig | Recipient | |
|---|---|---|---|
| Body weight (kg) | 100 | 110 | 85 |
| Heart weight (g) | 454 (397-492) | 328 | - |
| HW:BW ratio (g/kg) | 4.6 (4.0-4.9) | 2.98 | - |
| Total ventricular mass (g) | 321 (280-349) | 232a | 196.81b |
| VM:BW ratio (g/kg) | 3.2 (2.8-3.5) | 2.1 | 2.3 |
| LV mass (g) | 244c | 177c/163d | 171.84b |
| RV mass (g) | 76c | 55c | 24.97b |
| Ao diameter (mm) | 23 (20-24) | 16.6 | 38.2 |
| PA diameter (mm) | 24 (23-25) | 19.3 | 34.4 |
| Ao:VM ratio (mm/g) | 0.072 | 0.072 | - |
| PA:VM ratio (mm/g) | 0.075 | 0.083 | - |
Ao = ascending aorta; BW = body weight; GHRKO = growth hormone receptor knockout; HW = heart weight; LV = left ventricle; PA = pulmonary artery; RV = right ventricle; VM = ventricular mass; WT = wild-type.
a
Calculated on the basis of WT pig heart ratios.
b
Predicted on the basis of Reed et al.12
c
Predicted on the basis of Booth et al.11
d
Estimated on the basis of 3-dimensional volumetric reconstruction on CT.