Table 5.

Indirect effects of patient characteristics on prescribing intention: injection drug use indirect effects

Mediator	Patient injection drug use effectsa
	MID (1) vs. MSM (0)						MID (1) vs. MSW (0)
	Relative indirect effect	SE	95% CI	Partially standardized relative indirect effect	SE	95% CI	Relative indirect effect	SE	95% CI	Partially standardized relative indirect effect	SE	95% CI
HIV risk	0.01	0.02	[− 0.02, 0.05]	0.02	0.03	[− 0.03, 0.08]	0.03	0.04	[− 0.05, 0.12]	0.04	0.07	[− 0.08, 0.20]
Increased risk behavior	0.00	0.01	[− 0.01, 0.03]	0.01	0.02	[− 0.02, 0.05]	0.00	0.01	[− 0.01, 0.03]	0.01	0.02	[− 0.02, 0.05]
PrEP adherence	− 0.09	0.04	[− 0.17, − 0.02]*	− 0.14	0.06	[− 0.27, − 0.03]*	− 0.04	0.02	[− 0.10, − 0.01]*	− 0.07	0.04	[− 0.15, − 0.01]*
Importance of request	− 0.02	0.03	[− 0.09, 0.04]	− 0.03	0.05	[− 0.14, 0.05]	0.03	0.03	[− 0.03, 0.09]	0.04	0.05	[− 0.05, 0.14]
Investment in helping	0.00	0.01	[− 0.02, 0.01]	0.00	0.01	[− 0.03, 0.02]	0.00	0.01	[− 0.01, 0.03]	0.01	0.01	[− 0.02, 0.04]
Deservingness of help	0.01	0.01	[− 0.03, 0.03]	0.01	0.02	[− 0.05, 0.05]	0.03	0.02	[0.00, 0.07]*b	0.04	0.03	[0.00, 0.12]*c
Safety-consciousness	0.06	0.04	[− 0.01, 0.15]	0.09	0.06	[− 0.02, 0.23]	0.05	0.04	[− 0.01, 0.13]	0.08	0.06	[− 0.02, 0.20]
Responsibility	− 0.08	0.04	[− 0.17, − 0.01]*	− 0.12	0.06	[− 0.26, − 0.01]*	− 0.06	0.03	[− 0.14, − 0.01]*	− 0.09	0.05	[− 0.21, − 0.01]*
	Relative direct effect	SE	95% CI	Partially standardized relative direct effect			Relative direct effect	SE	95% CI	Partially standardized relative direct effect
	− 0.18	0.09	[− 0.35, − 0.01]*	− 0.28			− 0.17	0.09	[− 0.35, 0.01]	− 0.27
	Relative total effect	SE	95% CI	Partially standardized relative total effect			Relative total effect	SE	95% CI	Partially standardized relative total effect
	− 0.28	0.09	[− 0.47, − 0.10]*	− 0.45			− 0.13	0.09	[− 0.32, 0.05]	− 0.21
Significant specific indirect effects contrasted	Contrast effectd	SE	95% CI	Partially standardized contrast effect	SE	95% CI	Contrast effectd	SE	95% CI	Partially standardized contrast effect	SE	95% CI
PrEP adherence vs. deservingness of help	–	–	–	–	–	–	0.00	0.03	[− 0.06, 0.08]	0.00	0.05	[− 0.09, 0.12]
PrEP adherence vs. responsibility	0.04	0.07	[− 0.10, 0.18]	0.07	0.11	[− 0.16, 0.28]	− 0.05	0.05	[− 0.16, 0.05]	− 0.08	0.08	[− 0.25, 0.08]
Deservingness of help vs. responsibility	–	–	–	–	–	–	− 0.05	0.05	[− 0.16, 0.04]	− 0.08	0.08	[− 0.12, 0.10]

MSM man who has sex with men, MSW man who has sex with women, MID man who injects drugs

^aBased on bootstrapped analysis of parallel multiple mediator model with multicategorical predictor (patient risk behavior) adjusting for age, gender, race, sexual orientation, provider type, HIV specialization, practice setting, PrEP familiarity, PrEP experience, and patient race (Black or White). Indirect, direct, and total effects reported are relative effects because patient risk behavior is multicategorical

^b95% CI [0.0005, 0.0720] without rounding and therefore statistically significant

^c95% CI [0.0007, 0.1157] without rounding and therefore statistically significant

^dContrasts effects represent the difference in absolute magnitude of two specific indirect effects (mediational pathways). Only contrast effects involving significant specific indirect effects are shown. The patient risk multicategorical variable was recoded into dichotomous variables to generate contrast effects

^*p < 0.05