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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: J Autoimmun. 2020 Feb 11;109:102423. doi: 10.1016/j.jaut.2020.102423

Figure 1. HRD1 structure and its substrates.

Figure 1.

HRD1 protein has six N-terminal transmembrane domains (TMDs), a RING finger domain, and C-terminal proline-rich (PR) cytoplasmic tail. The HRD1 binding proteins, functional consequences of their interactions and possible disease associations are highlighted.