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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Adv Exp Med Biol. 2022;1371:33–59. doi: 10.1007/5584_2021_649

Fig. 2.

Fig. 2

The PDE superfamily The family name is indicated to the left with the number in parentheses indicating the number of genes in that family. Gray lines indicate the length of the primary sequence of a representative isoform of each family containing multiple genes and/or isoforms. Designations for the structural elements are catalytic domain (purple); CaM, calmodulin binding sites; GAFa and GAFb, ligand binding domain found in cGMP-binding PDEs, Anabaena adenylyl cyclase, and E. coli FhlA; TM, transmembrane region; UCR1 and UCR2, upstream conserved regions; P, C-terminal prenylation site; REC, cheY-homologous receiver domain; PAS, Per-Arnt-Sim domain. Adapted from [121].