Table 5.
Significantly changed ceramides in the T2DM and PreDM vs. NC.
| Lipids | Discovery set | Validation set | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PreDM vs. NC | T2DM vs NC | PreDM vs. NC | T2DM vs NC | |||||||||
| p | FDR | FC | p | FDR | FC | p | FDR | FC | p | FDR | FC | |
| Cer(d18:1/16:0) | 3.78E-03 | 3.27E-02 | 1.08 | 2.98E-06 | 9.07E-06 | 1.16 | 4.45E-02 | 1.14E-01 | 1.05 | 3.63E-05 | 1.85E-04 | 1.12 |
| Cer(d18:1/18:0) | 9.19E-03 | 4.65E-02 | 1.14 | 1.12E-05 | 2.97E-05 | 1.22 | 7.32E-03 | 3.32E-02 | 1.15 | 6.73E-05 | 2.83E-04 | 1.20 |
| Cer(d16:1/22:0) | 3.78E-02 | 1.04E-01 | 1.09 | 7.43E-09 | 6.47E-08 | 1.29 | 5.91E-03 | 2.99E-02 | 1.19 | 2.70E-06 | 2.91E-05 | 1.33 |
| Cer(d18:1/22:0) | 2.55E-02 | 8.11E-02 | 1.06 | 7.56E-07 | 2.78E-06 | 1.19 | 1.60E-02 | 5.61E-02 | 1.10 | 9.29E-07 | 1.44E-05 | 1.21 |
| Cer(d18:1/23:0) | 5.14E-03 | 3.61E-02 | 1.09 | 2.42E-06 | 7.67E-06 | 1.18 | 4.86E-02 | 1.20E-01 | 1.09 | 6.88E-05 | 2.88E-04 | 1.19 |
| Cer(d18:1/24:0) | 4.66E-03 | 3.41E-02 | 1.08 | 3.93E-07 | 1.60E-06 | 1.19 | 3.13E-02 | 8.94E-02 | 1.10 | 3.43E-06 | 3.36E-05 | 1.20 |