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. 2022 Aug 18;12:808021. doi: 10.3389/fonc.2022.808021

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Copyright © 2022 Walker, Chang, Henegar, Kashyap, Shacham, Sommer, Wick, Levy and Landesman

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression analysis in treated xenografts compared to matched vehicle controls. (A) Principal component analysis (PCA) analysis of gene-level expressions in vehicle treated control tumors for the indicated PDX models. Each dot represents one tumor. (B) Venn diagram indicating the number of genes differentially expressed in selinexor treated tumors compared to match vehicle controls. (C–E) Volcano plots show comparison of all expression of genes between indicated treatment group and vehicle control for CF466 (C) SF8894 (D) and CF365 (E) models. Y-axis is significance and x-axis is fold change. Top significant genes are labeled. XPO1 is indicated with a box.