Table 1.
Change in HDL-c and HDL subclass in breast cancer patients
| Study | Patient enrolled | High Density Lipoproteins |
|---|---|---|
| [134] |
N = 48 early-stage cancerous breast tumour patients N = 40 non-cancerous breast tumour patients |
↓ HDL-c in breast cancer patients vs. non-cancerous patients |
| [135] |
N = 83 breast cancer patients (Stage I-IV) N = 83 healthy patients |
↓ HDL-c in Stage IV breast cancer patients vs. healthy patients |
| [136] |
N = 58 breast cancer patients N = 105 healthy patients |
No change in HDL-c vs. healthy patients |
| [132] |
N = 30 breast cancer patients N = 30 healthy patients |
↓ HDL-c, HDL2 and HDL3 vs. healthy patients, an effect more pronounced for HDL-2 (-41%) than HDL-3 (-8%) |
| [131] |
N = 56 postmenopausal breast cancer patients (Stage II-IV) N = 44 healthy patients |
↓ HDL-c, HDL2 and HDL3 vs. healthy patients Furthermore, advancement of disease affects lipid profile where, ↓ HDL-c in Stage IV breast cancer patients vs. Stage II breast cancer patients |
| [137] |
N = 90 breast cancer patients N = 103 healthy patients |
↓ HDL-c in breast cancer patients vs. healthy patients |
| [138] |
N = 100 breast cancer patients (Stage I-IV) N = 50 healthy patients |
No change in HDL-c in breast cancer patients vs. healthy patients |
| [139] |
N = 17 postmenopausal breast cancer patients N = 30 postmenopausal healthy patients |
No change in HDL-c in breast cancer patients vs. healthy patients |
| [128] |
N = 125 breast cancer patients (Stage I -IV) N = 70 healthy patients |
↓ HDL-c breast cancer patients vs. healthy patients |
| [140] |
N = 100 pre- and postmenopausal breast cancer patients N = 100 healthy patients |
No change in HDL-c in breast cancer patients vs. healthy patients |
| [127] |
N = 120 breast cancer patients N = 60 healthy patient |
No change in HDL-c vs. healthy patients |
| [141] |
N = 60 pre- and postmenopausal breast cancer patients N = 60 healthy patients |
No change in HDL-c vs. healthy patients |
| [142] |
N = 249 early stage breast cancer patients N = 154 healthy patients |
↓ HDL-c in breast cancer patients ≤ 50 years old vs. healthy patients ↑ HDL-c in breast cancer patients ≥ 50 years old vs. healthy patients |
| [133] |
N = 56 breast cancer patients (Stage I-II) No healthy patients included as controls |
Large HDL subfractions associated with breast tumours expressing the progesterone receptor |
| [143] |
N = 150 breast cancer patients N = 75 healthy patients |
Unchanged HDL-c vs. healthy patients |
| [144] |
N = 1054 breast cancer patients N = 2483 healthy patients |
↓ HDL-c in breast cancer patients < 60 years old vs. healthy patients Unchanged HDL-c in breast cancer patients > 60 years old vs. healthy patients |
HDL-c High-density lipoprotein-cholesterol, vs. Versus