Table 1.

Summary of TP53 variations for 204 colorectal carcinoma patients

	Total n = 149	Missense n = 108	Nonsense n = 23	Frameshift n = 18
Functional domains
Transactivation	0	0	0	0
Proline rich region	3	0 (0%)	0 (0%)	3 (16.7%)
DNA binding region	129	106 (98.1%)	10 (43.5%)	13 (72.2%)
Nuclear localization signalling	6	0 (0%)	6 (26.1%)	0 (0%)
Tetramerization	9	1 (0.9%)	7 (30.4%)	1 (5.6%)
Regulatory	2	1 (0.9%)	0 (0%)	1 (5.6%)
Sub-regions of DB domain
L2	31	28 (25.9%)	1 (4.3%)	2 (11.1%)
L3	22	20 (18.5%)	1 (4.3%)	1 (5.6%)
LSH	31	31 (28.7%)	0 (0%)	0 (0%)
Other	65	29 (26.9%)	21 (91.3%)	15 (83.3%)
Exons
Exon4	9	1 (0.9%)	1 (4.3%)	7 (38.9%)
Exon5	36	33 (30.6%)	1 (4.3%)	2 (11.1%)
Exon6	22	12 (11.1%)	7 (30.4%)	3 (16.7%)
Exon7	26	24 (22.2%)	0 (0%)	2 (11.1%)
Exon8	44	35 (32.4%)	7 (30.4%)	2 (11.1%)
Exon9	1	0 (0%)	1 (4.3%)	0 (0%)
Exon10	10	2 (1.9%)	6 (26.1%)	1 (5.6%)
Exon11	2	1 (0.9%)	0 (0%)	1 (5.6%)