Table 2.
Correlation of TP53 variation with two different cut-off points for immunohistochemical expression of p53
| p53 IHC (DO-7) | p | p53 IHC (DO-7) | p | p53 IHC (Bp53–11) | p | p53 IHC (Bp53–11) | p | p53 IHC (SP5) | p | p53 IHC (SP5) | p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wild type pattern (1 ~ 79%) | Aberrant type pattern (0% or ≥ 80%) | Negative (≤55%) | Positive (> 55%) | Wild type pattern (1 ~ 49%) | Aberrant type pattern (0% or > 50%) | Negative (≤50%) | Positive (> 50%) | Wild type pattern (2 ~ 69%) | Aberrant type pattern (≤1% or ≥ 70%) | Negative (≤30%) | Positive (> 30%) | ||||||||
| All cases | 204 | 53 (26%) | 151 (74%) | 80 (39.2%) | 124 (60.8%) | 49 (24%) | 155 (76%) | 88 (43.1%) | 116 (56.9%) | 54 (26.5%) | 150 (73.5%) | 65 (31.9%) | 139 (68.1%) | ||||||
| TP53variation status | |||||||||||||||||||
| Wild type | 55 | 34 (61.8%) | 21 (38.2%) | 38 (69.1%) | 17 (30.9%) | 38 (69.1%) | 17 (30.9%) | 41 (74.5%) | 14 (25.5%) | 42 (76.4%) | 13 (23.6%) | 27 (49.1%) | 28 (50.9%) | ||||||
| Mutant type | 149 | 19 (12.8%) | 130 (87.2%) | < 0.001 | 42 (28.2%) | 107 (71.8%) | < 0.001 | 11 (7.4%) | 138 (92.6%) | < 0.001 | 47 (31.5%) | 102 (68.5%) | < 0.001 | 12 (8.1%) | 137 (91.9%) | < 0.001 | 38 (25.5%) | 111 (74.5%) | 0.001 |