Table 3.
Correlation between p53 immunohistochemical expression pattern and TP53 variation type
| Total | p53 IHC (DO-7) | p | p53 IHC (Bp53–11) | p | p53 IHC (SP5) | p | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wild type pattern (1 ~ 79%) |
Aberrant type pattern | Wild type pattern (1 ~ 49%) | Aberrant type pattern | Wild type pattern (2 ~ 69%) | Aberrant type pattern | ||||||||
| Nonsense/frameshift pattern (0%) | Missense pattern (≥80%) | Nonsense/frameshift pattern (0%) | Missense pattern (> 50%) | Nonsense/frameshift pattern (≤1%) | Missense pattern (≥70%) | ||||||||
| All cases | 204 | 53 (26%) | 40 (19.6%) | 111 (54.4%) | 49 (24%) | 39 (19.1%) | 116 (56.9%) | 54 (26.5%) | 45 (22.1%) | 105 (51.5%) | |||
| TP53variation status | |||||||||||||
| Wild type | 55 | 34 (61.8%) | 9 (16.7%) | 11 (20.4%) | 38 (70.4%) | 2 (3.7%) | 14 (25.9%) | 42 (77.8%) | 7 (13%) | 5 (9.3%) | |||
| Missense variation | 108 | 12 (11.1%) | 2 (1.8%) | 95 (87.2%) | 7 (6.4%) | 2 (1.8%) | 100 (91.7%) | 8 (7.3%) | 2 (1.8%) | 99 (90.8%) | |||
| Nonsense/frameshift variation | 41 | 7 (17.1%) | 29 (70.7%) | 5 (12.2%) | < 0.001 | 4 (9.8%) | 35 (85.4%) | 2 (4.9%) | < 0.001 | 4 (9.8%) | 36 (87.8%) | 1 (2.4%) | < 0.001 |