Table 9.
Multivariate Cox regression analysis for overall survival and relapse-free survival in colorectal cancer patients
| Characteristics | OS | RFS | ||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Model 1 | ||||
| Histologic grade, Poor (vs. Well or Moderate) | 3.375 (1.431–7.964) | 0.005 | 0.828 (0.328–2.092) | 0.69 |
| N stage, 1–3 (vs. N stage, 0) | 0.61 (0.094–3.982) | 0.606 | 4.262 (1.826–9.943) | 0.001 |
| TNM Stage, III or IV (vs. TNM Stage, I or II) | 2.543 (0.981–6.592) | 0.055 | 1.123 (0.212–5.946) | 0.892 |
| p53 (DO-7) IHC, positive, > 55% (vs. negative, ≤55%) | 4.098 (1.197–14.031) | 0.025 | 0.77 (0.371–1.599) | 0.483 |
| Model 2 | ||||
| Histologic grade, Poor (vs. Well or Moderate) | 3.114 (1.323–7.33) | 0.009 | 0.852 (0.338–2.148) | 0.734 |
| N stage, 1–3 (vs. N stage, 0) | 0.683 (0.101–4.632) | 0.696 | 4.262 (1.826–9.943) | 0.001 |
| TNM Stage, III or IV (vs. TNM Stage, I or II) | 2.76 (1.067–7.142) | 2.76 | 1.113 (0.209–5.917) | 0.9 |
| p53 (Bp53–11) IHC, positive, > 50% (vs. negative, ≤50%) | 2.531 (0.926–6.918) | 0.07 | 0.759 (0.369–1.56) | 0.452 |
| Model 3 | ||||
| Histologic grade, Poor (vs. Well or Moderate) | 3.04 (1.288–7.178) | 0.011 | 0.854 (0.338–2.156) | 0.738 |
| N stage, 1–3 (vs. N stage, 0) | 0.587 (0.081–4.242) | 0.598 | 4.262 (1.826–9.943) | 0.001 |
| TNM Stage, III or IV (vs. TNM Stage, I or II) | 2.674 (1.036–6.903) | 0.042 | 1.125 (0.214–5.928) | 0.889 |
| p53 (SP5) IHC, positive, > 30% (vs. negative, ≤30%) | 9.897 (1.327–73.831) | 0.025 | 0.788 (0.371–1.676) | 0.536 |
| Model 4 | ||||
| Histologic grade, Poor (vs. Well or Moderate) | 3.077 (1.312–7.221) | 0.01 | 0.836 (0.33–2.114) | 0.705 |
| N stage, 1–3 (vs. N stage, 0) | 0.722 (0.083–6.314) | 0.769 | 4.262 (1.826–9.943) | 0.001 |
| TNM Stage, III or IV (vs. TNM Stage, I or II) | 3.122 (1.219–8) | 0.018 | 1.115 (0.211–5.878) | 0.898 |
Model 1 variables: Sex, Age, Histologic grade, Site, Tumor size, T stage, N stage, Stage, CEA, p53 (D07) IHC Negative/Positive
Model 2 variables: Sex, Age, Histologic grade, Site, Tumor size, T stage, N stage, Stage, CEA, p53 (Bp53–11) IHC Negative/Positive
Model 3 variables: Sex, Age, Histologic grade, Site, Tumor size, T stage, N stage, Stage, CEA, p53 (SP5) IHC Negative/Positive
Model 4 variables: Sex, Age, Histologic grade, Site, Tumor size, T stage, N stage, Stage, CEA, TP53 NGS, Wild type/ Variation type