Table 1.
Medical history timeline during the first 1.8 years of life and biochemical and hormonal values
| Chronologic Age(years) | 40 + 3 weeks of GA (Birth) | 46 + 6 weeks of GA (First hospitalization) | 0.17(First discharge) | 0.22 (Second hospitalization) | 0.27 (Second discharge) | 0.39 | 0.65 | 0.94 | 1.36 | 1.75 (Death) |
|---|---|---|---|---|---|---|---|---|---|---|
| Length(cm) | / | 61 | / | 64 | / | 64.6 | 68 | 70 | 75 | 76 |
| Weight(Kg) | 3.3 | 3.5 | / | 4.3 | 4.8 | 6.2 | 8 | 8.3 | 9.6 | 10.4 |
| Head Circumference(cm) | / | / | / | / | / | / | / | / | / | / |
| ACTH(7.2–63.6 pg/ml) | / | / | 15.04 | 8.76 | 72.83 | 4.48 | 3.42 | 3.86 | 2.36 | / |
| Cortisol(66–630 nmol/L) | / | / | 647.9 | 874.4 | 12.72 | 29.88 | 11.57 | 6.41 | 7.64 | / |
| LH(1.5–12.4 IU/L) | / | / | / | 7.23 | / | / | / | 1.76 | 0.46 | / |
| FSH(0.1–5.4 IU/L) | / | / | / | 13.93 | / | / | / | 0.73 | 0.1 | / |
| E2(18-73 pmol/L) | / | / | / | 18.4 | / | / | / | 18.4 | 57.1 | / |
| P(0.7–4.3 nmol/L) | / | / | / | 0.1 | / | / | / | 0.1 | 0.65 | / |
| T(0.1–1.12 nmol/L) | / | / | / | 13.03 | / | / | / | 0.09 | 0.09 | / |
| PRL(106–713 mIU/L) | / | / | / | 518.3 | / | / | / | 131.6 | 243.6 | / |
| 17-α-OHP(0–1.54 ng/ml) | / | / | 0.48 | 0.52 | / | / | / | / | / | / |
| ALT(0–40 U/L) | / | 141.1 | 62.8 | 115 | 138 | 233 | 153 | 181 | 183 | 439 |
| AST(0–40 U/L) | / | 88.8 | 53.3 | 121 | 173 | 253 | 163 | 206 | 212 | 1078 |
| ALP(147.7–309.3 U/L) | / | 50.7 | 147.2 | 247 | 252 | 210 | 149 | 155 | 123 | 140.8 |
| CK(16.5–211.5 U/L) | / | 1584 | 621 | 2620 | 6771 | 11,622 | 10,680 | 13,512 | 9822 | 26,055.3 |
| CK-MB(15–80 U/L) | / | 203.1 | 97 | 254 | 343 | 540 | 520 | 538 | 549 | 2353 |
| LDH(67–394.1 U/L) | / | 402.3 | 367.4 | / | 617 | 959 | 815 | 956 | 946 | 2440.4 |
| LDH-MB(30–120 U/L) | / | 125.4 | 64.9 | / | 88 | 116 | 97 | 101 | 110 | 165.2 |
| TCHOL(3.12–5.2 mmol/L) | / | / | / | 4.86 | 5.18 | 4.76 | 4.28 | 4.46 | 4.53 | / |
| α-HBDH(75.5–211.5 U/L) | / | 314 | 255.2 | 300 | 447 | 631 | 545 | 624 | 617 | 1560.9 |
| TG(0.8–1.8 mmol/L) | / | / | / | 12.01 | 8.87 | 4.76 | 6.71 | 6.09 | 4.53 | / |
| Apo-A(1–1.6 g/L) | / | / | / | 1.67 | 1.45 | 1.68 | 1.43 | 1.65 | 1.74 | / |
| Apo-B(0.6–1.1 g/L) | / | / | / | 0.6 | 0.8 | 0.67 | 0.6 | 0.49 | 0.61 | / |
| Na(135–145 mmol/L) | / | 133 | 130.4 | 132 | 136 | 139 | 142 | 141 | 143 | 140.8 |
| K (3.5–5.5 mmol/L) | / | 4.6 | 5.1 | 6.7 | 6.6 | 5 | 4.4 | 3.7 | 4.2 | 5.7 |
| Ca(2.2–2.7 mmol/L) | / | 2.39 | 2.33 | 2.86 | 2.68 | 2.62 | 2.53 | 2.34 | 2.32 | 1.97 |
| Mg(0.6–0.95 mmol/L) | / | 0.74 | 0.7 | 0.81 | 0.89 | 0.88 | 0.79 | 0.78 | 0.9 | 1.26 |
| Cl(96–106 mmol/L) | / | 110.7 | 97.6 | 94 | 96 | 101 | 102 | 103 | 101 | 98 |
| Phosphorus(1.45–2.1 mmol/L) | / | 1.08 | 1.54 | 2.11 | 2.45 | 2.16 | 1.84 | 1.76 | 1.78 | 3.48 |
| Lac(0.5–2.2 mmol/L) | / | 1 | 2.5 | 4.2 | / | / | / | / | / | 10.1 |
| Glu(3.9–5.8 mmol/L) | / | 3.27 | 4.5 | 4.1 | 5.4 | / | 3.6 | / | / | 1.7 |
| Medication | given hydrocortisone acetate intravenously, 5 mg, q8h + oral fludrocortisone, 0.1 mg/d | oral hydrocortisone acetate, 5 mg in the morning, 2.5 mg at noon and 2.5 mg at night + oral fludrocortisone, 0.1 mg/d + salt supplementation 2 g/day | oral hydrocortisone acetate, 5 mg- 2.5 mg- 2.5 mg + oral fludrocortisone, 0.1 mg/d + salt supplementation 2 g/day | same as the previous | oral hydrocortisone acetate, 2 mg- 2 mg- 2 mg + oral fludrocortisone, 0.1 mg/d + salt supplementation 2 g/day | same as the previous | same as the previous | same as the previous | / |
GA Gestational age, ACTH Adrenocorticotropic hormone, LH Luteinizing hormone, FSH Follicle stimulating hormone, E2 Estradiol, P Progesterone, T Testosterone, PRL Prolactin, 17-α-OHP 17-alpha hydroxyprogesterone, ALT Alanine transaminases, AST Aspartate transaminases, ALP Alkaline phosphatase, CK Creatine kinase, CK-MB Creatine kinase isoenzyme, LDH Lactate dehydrogenase, LDH-MB Lactate dehydrogenase isoenzyme, TCHOL Total cholesterol, α-HBDH α-hydroxybutyrate, TG Triglycerides, Na Sodium, K Potassium, Ca Calcium, Mg Magnesium, Cl Chlorine, Lac Lactic acid, Glu Glucose