Table 4.
The interaction of MC4R genotypes and MND on CVD risk factors*
| Variables | models | alleles | T2 | T3 | ||||
|---|---|---|---|---|---|---|---|---|
| β | 95% CI | P-value | β | 95% CI | P-value | |||
| BMI (kg/m2) | Crude | TT | References | 0.70 | References | 0.93 | ||
| TC + CC | 0.58 | -2.46 to 3.63 | 0.12 | -2.85 to 3.10 | ||||
| Adjusted | TT | References | 0.71 | References | 0.94 | |||
| TC + CC | 0.50 | -2.18 to 3.20 | -0.08 | -2.71 to 2.54 | ||||
| WC (cm) | Crude | TT | References | 0.58 | References | 0.70 | ||
| TC + CC | 1.95 | -5.13 to 9.04 | 1.34 | -5.58 to 8.26 | ||||
| Adjusted | TT | References | 0.57 | References | 0.77 | |||
| TC + CC | 1.94 | -4.85 to 8.74 | 0.97 | -5.66 to 7.62 | ||||
| WHR | Crude | TT | References | 0.36 | References | 0.99 | ||
| TC + CC | 1.75 | -2.05 to 5.56 | 0.01 | -3.70 to 3.73 | ||||
| Adjusted | TT | References | 0.39 | References | 0.85 | |||
| TC + CC | 1.87 | -2.41 to 6.16 | -0.40 | -4.58 to 3.78 | ||||
| BFM (kg) | Crude | TT | References | 0.42 | References | 0.54 | ||
| TC + CC | 2.50 | -3.60 to 8.60 | 1.86 | -4.10 to 7.82 | ||||
| Adjusted | TT | References | 0.49 | References | 0.79 | |||
| TC + CC | 1.99 | -3.66 to 7.66 | 0.73 | -4.79 to 6.26 | ||||
| FFM (kg) | Crude | TT | References | 0.98 | References | 0.40 | ||
| TC + CC | 0.03 | -3.84 to 3.90 | -1.62 | -5.40 to 2.16 | ||||
| Adjusted | TT | References | References | 0.32 | ||||
| TC + CC | -0.21 | -4.19 to 3.75 | 0.91 | -1.95 | -5.84 to 1.92 | |||
| VFL | Crude | TT | References | 0.07 | References | 0.03 | ||
| TC + CC | -9.23 | -19.25 to 0.79 | -10.84 | -20.64 to -1.04 | ||||
| Adjusted | TT | References | 0.07 | References | 0.03 | |||
| TC + CC | -10.25 | -21.53 to 1.02 | -12.22 | -23.24 to -1.20 | ||||
| HOMA-IR | Crude | TT | References | 0.54 | References | 0.87 | ||
| TC + CC | 0.29 | -0.65 to 1.23 | -0.07 | -1.06 to 0.90 | ||||
| Adjusted | TT | References | 0.70 | References | 0.82 | |||
| TC + CC | 0.19 | -0.81 to 1.21 | 0.11 | -0.93 to 1.17 | ||||
| Total Cholesterol (mg/dl) | Crude | TT | References | 0.01 | References | 0.06 | ||
| TC + CC | -34.64 | -61.30 to -7.97 | -24.24 | -49.87 to 1.38 | ||||
| Adjusted | TT | References | < 0.001 | References | 0.20 | |||
| TC + CC | -38.79 | -65.00 to -12.58 | -16.29 | -41.35 to 8.77 | ||||
| TG (g/dl) | Crude | TT | References | 0.62 | References | 0.79 | ||
| TC + CC | -13.17 | -65.80 to 39.44 | -6.70 | -57.28 to 43.87 | ||||
| Adjusted | TT | References | 0.61 | References | 0.72 | |||
| TC + CC | -14.31 | -70.39 to 41.76 | 9.51 | -44.11 to 63.15 | ||||
| HDL (mg/dl) | Crude | TT | References | 0.75 | References | 0.46 | ||
| TC + CC | -1.30 | -9.53 to 6.92 | -2.94 | -10.85 to 4.96 | ||||
| Adjusted | TT | References | 0.77 | References | 0.72 | |||
| TC + CC | 1.23 | -7.25 to 9.71 | -1.44 | -9.56 to 6.67 | ||||
| LDL (mg/dl) | Crude | TT | References | 0.01 | References | 0.17 | ||
| TC + CC | -21.69 | -39.71 to -3.67 | -11.90 | -29.22 to 5.41 | ||||
| Adjusted | TT | References | 0.03 | References | 0.53 | |||
| TC + CC | -18.77 | -36.59 to -0.95 | -5.41 | -22.45 to 11.62 | ||||
| LDL/HDL | Crude | TT | References | 0.06 | References | 0.52 | ||
| TC + CC | -0.08 | -0.18 to 0.00 | -0.02 | -0.11 to 0.06 | ||||
| Adjusted | TT | References | 0.04 | References | 0.70 | |||
| TC + CC | -0.96 | -0.19 to -0.00 | -0.01 | -0.10 to 0.07 | ||||
| CHOL/HDL | Crude | TT | References | 0.06 | References | 0.20 | ||
| TC + CC | -1.08 | -1.81 to 0.39 | -0.70 | -1.81 to 0.39 | ||||
| Adjusted | TT | References | 0.01 | References | 0.19 | |||
| TC + CC | -1.50 | -2.23 to 0.05 | -0.76 | -1.91 to 0.39 | ||||
| hs-CRP (mg/ L) | Crude | TT | References | 0.07 | References | 0.34 | ||
| TC + CC | -3.24 | -6.76 to 0.26 | -1.63 | -4.99 to 1.72 | ||||
| Adjusted | TT | References | 0.12 | References | 0.51 | |||
| TC + CC | -2.90 | -6.62 to 0.80 | -1.17 | -4.72 to 2.37 | ||||
TT genotype has 0 risk allele. TC genotype has one and CC genotype have two risk alleles
TT genotype and Low adherence to MND are considered as references
Generalized linear model; crude model and adjusted model to BMI, physical activity, kcal, age, family history of obesity, and occupation, as covariates
BMI Body mass index, WC waist circumference, WHR waist height ratio, BFM body fat mas, FFM fat free mass, VFL visceral fat level, TG Triglyceride, LDL Low density lipoprotein, HDL, High density lipoprotein, CHOL cholesterol, hs-CRP High sensitivity C-reactive protein
*For interactions, P < 0.1 was considered significant