Figure 4.

Pedigree of the HM-78 family showing the results of segregation analyses of rs1581364290, rs200661444, and rs246073 in the PCDHA10 gene. Individuals with HM are indicated by black-filled symbols and control individuals by the open symbols, whereas symbol with M represents individual (21 years old) with myopia (OD: –4.0 D, axial length (AL) 24.11 mm, OS: –4.5 D, AL 24.82 mm). Individuals assessed in the segregation analysis are numbered under their symbols in the pedigree. Exome sequencing was applied for individuals with the underlined numbers. Members HM-78-07, HM-78-10, HM-78-11, and HM-78-08 carried a 16,794-bp deletion, starting in exon 1 of PCDHA8 and ending in intron 1 of PCDHA10 (marked by “del”).