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. 2022 Aug 29;63(9):32. doi: 10.1167/iovs.63.9.32

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Figure 1. — Alpha and Beta Diversity for patient eyes treated with eyedrops and no-drops compared to healthy control eyes. (A) Patient eyes treated with eyedrops (n = 16) exhibited significantly greater alpha-diversity measures compared to healthy control eyes (n = 24) in Shannon diversity (P = 5.23e-6, Kruskal-Wallis). There were also significant differences in microbial composition, demonstrated by principal coordinate analysis of beta diversity, between patient eye samples with eyedrops compared to controls. (B) Differences were seen in beta-diversity based on Bray Curtis distances (P = 0.001, R² = 0.0565, PERMANOVA). (C) Patient eyes without eyedrops (n = 15) also exhibited significantly greater alpha-diversity measures compared to healthy controls (n = 24) in Shannon diversity (P = 7.65e-5, Kruskal-Wallis). There were significant differences in microbial composition between patient eye samples without eyedrops compared to controls. (D) Differences were seen in beta-diversity based on Bray Curtis distances (P = 0.001, R² = 0.0679, PERMANOVA). The axis values in the beta-diversity plot are the percentage of variance of phylogenetic beta diversity.