Table 4. Effect on Blood Glucose in STZ-Induced Diabetesa.
| blood
glucose level in mg/dL |
||||||
|---|---|---|---|---|---|---|
| groups | dose (mg/kg) | day 1 | day 7 | day 14 | day 21 | day 28 |
| normal control | 109.36 ± 4.70 | 109.43 ± 3.96 | 110.71 ± 4.88 | 108.81 ± 5.28 | 106.46 ± 5.11 | |
| diabetic control | 380.21 ± 5.29!!! | 379.31 ± 4.98!!! | 388.62 ± 5.03!!! | 401.08 ± 5.71!!! | 392.16 ± 5.02!!! | |
| 2B | 10 | 376.21 ± 4.23 | 286.09 ± 4.31* | 188.21 ± 4.32** | 144.31 ± 4.34** | 127.81 ± 4.23** |
| 20 | 381.09 ± 4.21 | 225.33 ± 4.87** | 155.09 ± 4.55** | 120.42 ± 4.88*** | 104.15 ± 3.99*** | |
| 3B | 10 | 373.11 ± 4.11 | 291.80 ± 4.71* | 190.87 ± 4.07* | 147.62 ± 5.01** | 132.11 ± 4.03** |
| 20 | 380.35 ± 5.08 | 234.78 ± 4.61** | 161.42 ± 4.12** | 122.56 ± 4.70*** | 105.32 ± 4.09*** | |
| 6B | 10 | 381.40 ± 4.30 | 280.90 ± 4.66* | 205.31 ± 4.01* | 150.45 ± 4.92** | 135.67 ± 3.89** |
| 20 | 380.30 ± 4.78 | 228.44 ± 5.06** | 166.09 ± 4.46** | 129.71 ± 4.09** | 111.81 ± 4.08*** | |
| 7B | 10 | 377.08 ± 5.01 | 290.20 ± 4.93 | 215.76 ± 5.03* | 153.19 ± 4.66* | 136.51 ± 5.19** |
| 20 | 374.21 ± 4.12 | 238.39 ± 5.11** | 171.44 ± 4.98* | 134.20 ± 5.03*** | 112.97 ± 4.56*** | |
| 12B | 10 | 371.67 ± 4.66 | 301.41 ± 4.56* | 209.60 ± 4.22* | 152.56 ± 4.71* | 138.92 ± 4.67* |
| 20 | 369.56 ± 4.56 | 237.11 ± 4.39** | 167.49 ± 5.02** | 131.69 ± 4.77** | 114.74 ± 5.09*** | |
| 13B | 10 | 370.81 ± 4.79 | 289.89 ± 4.33* | 200.33 ± 4.57** | 149.30 ± 4.56** | 132.98 ± 4.33** |
| 20 | 375.31 ± 5.01 | 230.71 ± 4.88** | 163.68 ± 4.37** | 120.72 ± 4.11*** | 108.42 ± 3.98*** | |
| 14B | 10 | 369.82 ± 4.12 | 294.04 ± 4.67 | 196.39 ± 4.12** | 151.11 ± 4.39* | 134.20 ± 4.21** |
| 20 | 370.33 ± 3.98 | 231.69 ± 5.20** | 158.26 ± 4.67** | 127.21 ± 4.81*** | 109.71 ± 4.23*** | |
| std | 0.5 | 352.28 ± 4.11 | 231.12 ± 4.29** | 151.43 ± 4.09** | 118.87 ± 4.03*** | 101.68 ± 4.19*** |
a
All values are expressed as means ± SEM, n = 8. One-way ANOVA and Dunnett’s post hoc multiple comparison test determines the values of P. !!!P < 0.001 as a comparison of the diabetic control group vs normal control, *P < 0.05, **P < 0.01, and ***P < 0.001 as a comparison of the diabetic control group vs test samples and glibenclamide-treated groups using one-way ANOVA followed by Dunnett’s comparison.