Table 5. Effect of the Target Compounds on the Body Weights of Ratsa.
| groups | dose (mg/kg) | day 1 | day 7 | day 14 | day 21 | day 28 |
|---|---|---|---|---|---|---|
| normal control | 173.1 ± 3.91 | 174.3 ± 4.01 | 174.8 ± 4.19 | 173.8 ± 4.09 | 176.1 ± 4.12 | |
| diabetic control | 180.2 ± 4.39 | 161.9 ± 4.12!! | 157.1 ± 4.37!!! | 154.2 ± 4.81!!! | 148.4 ± 4.01!!! | |
| glibenclamide | 0.5 | 187.4 ± 4.57 | 190.2 ± 3.98* | 177.1 ± 4.21* | 183.7 ± 4.33** | 185.1 ± 4.48** |
| 2B | 10 | 187.7 ± 4.61 | 185.1 ± 4.39* | 177.3 ± 4.51** | 179.4 ± 4.16* | 176.6 ± 4.98** |
| 20 | 192.1 ± 4.91 | 191.2 ± 4.39* | 180.1 ± 4.62** | 181.4 ± 3.98* | 181.6 ± 4.66** | |
| 3B | 10 | 191.3 ± 4.11 | 189.1 ± 4.31* | 186.5 ± 4.19** | 180.4 ± 4.76* | 177.3 ± 4.88** |
| 20 | 198.1 ± 4.66 | 193.0 ± 4.18* | 187.9 ± 4.21** | 184.1 ± 4.13* | 183.2 ± 4.68** | |
| 6B | 10 | 190.0 ± 3.98 | 182.5 ± 4.19* | 187.1 ± 4.88** | 183.4 ± 4.60* | 180.9 ± 4.23** |
| 20 | 194.1 ± 4.41 | 189.3 ± 4.61* | 190.3 ± 4.71** | 186.7 ± 3.96* | 184.3 ± 4.33** | |
| 7B | 10 | 191.1 ± 4.07 | 188.2 ± 4.57* | 185.6 ± 4.90** | 184.1 ± 4.71* | 183.7 ± 4.32** |
| 20 | 188.9 ± 4.67 | 190.8 ± 4.21* | 188.1 ± 4.62** | 185.2 ± 3.91* | 186.1 ± 4.58** | |
| 12B | 10 | 187.5 ± 4.39 | 185.1 ± 4.71* | 184.5 ± 4.06** | 187.0 ± 4.39* | 173.9 ± 4.28** |
| 20 | 189.7 ± 4.08 | 184.7 ± 4.66** | 187.1 ± 4.11** | 189.3 ± 4.60** | 175.3 ± 5.01** | |
| 13B | 10 | 186.6 ± 4.70 | 183.4 ± 4.15* | 186.3 ± 4.22** | 180.1 ± 4.12* | 177.3 ± 4.40** |
| 20 | 193.6 ± 4.21 | 187.2 ± 4.81* | 191.1 ± 4.14** | 187.8 ± 3.99* | 185.7 ± 4.79** | |
| 14B | 10 | 188.5 ± 4.07 | 186.8 ± 4.39* | 187.1 ± 4.33** | 181.6 ± 4.21* | 179.3 ± 4.41** |
| 20 | 189.1 ± 4.19 | 188.5 ± 4.21* | 189.2 ± 4.66** | 183.4 ± 4.18* | 182.5 ± 4.58** |
a
All values are expressed as means ± SEM, n = 8. One-way ANOVA and Dunnett’s post hoc multiple comparison test determines the values of P. !!!P < 0.001 as a comparison of the diabetic control group vs normal control, *P < 0.05, **P < 0.01, and ***P < 0.001 as a comparison of the diabetic control group vs test samples and glibenclamide-treated groups using one-way ANOVA followed by Dunnett’s comparison.