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The assortment of HIF1α and HIF2α functions in leukemias. In the leukemic BM microenvironment, high cellularity and oxygen consumption expose leukemic cells to hypoxia and promote the expression of HIF1α and HIF2α. HIFs and hypoxia exert a wide range of tumor-promoting functions in many leukemia types (CML, CLL, ALL, and AML). Amongst others: maintenance of LSCs, increased leukemic cell proliferation, metabolic switch to glycolysis, and chemoresistance are summarized in this figure.
