Table 1.
Vascular expression of key Notch signaling components and their role in vascular smooth muscle cell (VSMC) function and associated pathologies
| Notch signaling component | Vascular expression | Function in VSMCs | Associated vascular disease |
|---|---|---|---|
| Notch 1 | Endothelial cells (Takeshita et al. 2007), pericytes (Kofler et al. 2015), VSMCs (low basal expression) (Li et al. 2009) | Promotes proliferation + cell survival (Sweeney et al. 2004) | Adams–Oliver syndrome (Stittrich et al. 2014) |
| Aortic valve disease (Garg et al. 2005) | |||
| Notch 2 | VSMCs (large caliber vessels) (High et al. 2007; Varadkar et al. 2008) | Promotes differentiation (Baeten and Lilly 2015) + Jagged 1–mediated proliferation inhibition (Boucher et al. 2013) | Alagille syndrome (McDaniell et al. 2006) |
| Hajdu–Cheney (Simpson et al. 2011) | |||
| Notch 3 | Pericytes (Joutel et al. 2000), VSMCs (Domenga et al. 2004) | Promotes differentiation + mural cell investment (Domenga et al. 2004), promotes proliferation + cell survival (Liu et al. 2010) | Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (Joutel et al. 1996) |
| Infantile myofibromatosis (Wu et al. 2021) | |||
| Notch 4 | Endothelial cells (Wu et al. 2005) | - | - |
| Jagged 1 | VSMCs (High et al. 2007), endothelial cells (Lindner et al. 2001), pericytes (Kofler et al. 2015) | Promotes differentiation (Manderfield et al. 2012) | Alagille syndrome (Kamath et al. 2004) |
| Tetralogy of Fallot (Eldadah et al. 2001) | |||
| Dll1 | Endothelial cells (Sörensen et al. 2009) | - | - |
| Dll4 | Endothelial cells (Liu et al. 2003) | - | Adams–Oliver syndrome (Meester Josephina et al. 2015) |
Supportive references are included in the table.