Table 4.
Uni- and multivariable Cox regression analyses to assess association between the TR evolution groups and all-cause mortality
| All-cause mortality | ||
|---|---|---|
| HR (95% CI) | P-value | |
| Univariable analysis | ||
| Baseline Grade 0–1 TR unchanged | Reference group | |
| Baseline Grade 2–4 TR improved | 1.330 (0.975–1.815) | 0.071 |
| Baseline Grade 0–1 TR worsened | 2.126 (1.628–2.777) | <0.001 |
| Baseline Grade 2–4 TR unchanged | 2.157 (1.687–2.757) | <0.001 |
| Multivariable analysisa | ||
| Baseline Grade 0–1 TR unchanged | Reference group | |
| Baseline Grade 2–4 TR improved | 1.153 (0.814–1.633) | 0.424 |
| Baseline Grade 0–1 TR worsened | 1.745 (1.287–2.366) | <0.001 |
| Baseline Grade 2–4 TR unchanged | 1.572 (1.198–2.063) | 0.001 |
TR = tricuspid regurgitation.
a
Adjusted for age, gender, arterial hypertension, diabetes mellitus, hyperlipidaemia, body mass index, ischaemic aetiology of heart failure, atrial fibrillation, New York Heart Association functional class III–IV, estimated glomerular filtration rate, left ventricular end-systolic volume at 6 months, left ventricular ejection fraction at 6 months and relative change in RV ESA at 6 months.