Figure 2.

Genome-wide association studies (GWAS) test the association of common genetic variants with traits or diseases. Results are shown as a Manhattan plot (A) where the P-value (y-axis) is plotted against the genomic position (x-axis) for millions of common variants across the genome (blue markers). Polygenic risk scores (B) are generally derived from GWAS and calculated for an individual i (PRS_i) as the sum of the products of allelic dosage (dosage_ij) by the regression coefficient/weight (bj) for all M genetic variants (j). Created with Biorender.com.