Recommendation	Consensus statement instruction	Ref.
Genetic testing with sequencing of SCN5A is recommended for an index case diagnosed with BrS with a type I ECG in standard or high precordial leads occurring either (i) spontaneously, or (ii) induced by sodium-channel blockade in presence of supporting clinical features or family history.		21, 171
Rare variants in genes with a disputed or refuted gene-disease clinical validity should not be reported routinelya for BrS genetic testing in a diagnostic setting.		21
Targeted sequencing of variant(s) of unknown significance in SCN5A with a population allele frequency <1 × 10−5 identified in an index case can be considered concurrently with phenotyping for family members, following genetic counselling, to assess variant pathogenicity through co-segregation analysis.		172
Variant-specific genetic testing is recommended for family members and appropriate relatives following the identification of the disease-causative variant.		Expert opinion
Predictive genetic testing (of pathogenic SCN5A variants) in related children is recommended from birth onward (any age).		Expert opinion

^aUnless in a research setting.