Recommendation	Consensus statement instruction	Ref.
Genetic testing is recommended for probands with DCM and family history of DCM, and the initial tier of genes tested should include genes with definitive or strong evidence of pathogenicity (currently BAG3, DES, FLNC, LMNA, MYH7, PLN, RBM20, SCN5A, TNNC1, TNNT2, TTN, DSP).		19, 340
For genetic testing in a proband with DCM, the initial tier of genes tested may include genes with moderate evidence of pathogenicity (ACTC1, ACTN2, JPH2, NEXN, TNNI3, TPM1, VCL).		19
Genetic testing is recommended for patients with DCM and family history of premature unexpected sudden death or in a DCM patient with clinical features suggestive of a particular/rare genetic disease (such as atrioventricular block or sinus dysfunction or creatine phosphokinase elevation).		340
Genetic testing can be useful for patients with apparently sporadic DCM, particularly in the presence of either severe systolic dysfunction (left ventricular ejection fraction < 35%), or a malignant arrhythmia phenotype (e.g. sustained ventricular tachycardia/fibrillation), or particularly at a younger age.		340
Genetic testing may be considered for patients with DCM related to an acquired or environmental cause that may overlap with a genetic cause (such as peripartum or alcoholic cardiomyopathy).		341, 342
Genetic testing is useful for patients with DCM to improve risk stratification and guide therapy.		201, 343–348
Variant-specific genetic testing is recommended for family members and appropriate relatives following the identification of the disease-causative variant.		16, 340, 349
Predictive genetic testing in related children is recommended in those aged >10–12 years.		16, 350
Predictive genetic testing in related children aged below 10–12 years may be considered, especially where there is a family history of early-onset disease.		16, 350