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. 2022 Sep 1;132(17):e153519. doi: 10.1172/JCI153519

Figure 5. Ern2–/– mice have increased susceptibility to C. rodentium–and DSS-associated colitis.

Figure 5

(A and B) Time courses represent the onset of infection monitored by (A) the percentage of mice with C. rodentium detected in stool and (B) C. rodentium CFUs in stool. Time courses represent the average measured in 47 WT and 38 Ern2–/– mice from 5 independent experiments. (B) Bar graph shows C. rodentium CFUs in stool of infected mice at 8 days after infection. Symbols represent individual mice. Data are represented as mean ± SEM. Mean values were compared by unpaired t test. (C and D) Bar graphs show C. rodentium CFUs cultured from colon tissue and (D) histology scores of epithelial damage in control mice and infected mice at 8 and 13 days after infection. Symbols represent individual mice. Data are represented as mean ± SEM. Mean values were compared by 2-way ANOVA. (E and F) Time courses shows (E) change in body weight and (F) survival for WT and Ern2–/– mice during administration of DSS for 8 days followed by recovery for 14 days. Symbols represent average values (WT, n = 8; Ern2–/–, n = 8). Survival curves were compared using a log rank test. *P < 0.05.