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. 2022 Aug;32(8):1529–1541. doi: 10.1101/gr.276766.122

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© 2022 Hansen and Hodges; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — TF footprints stratify ATAC-STARR-deﬁned regulatory regions into gene regulatory networks. (A) ATAC-STARR-deﬁned chromatin accessibility, TF footprints, and regulatory regions at Chr 19: 35,611,232–35,798,446 (hg38). Signal tracks represent counts per million normalized read depth of chromatin accessibility. Zooms into ETV2 and ZBTB32 show that some regulatory regions are occupied by a SP1, KLF3, IRF8, or NFKB1 footprint. (B,C) Heat maps of clustered (B) active and (C) silent regions based on presence or absence of footprints for select TF motif archetypes. (D,E) Reactome pathway enrichment analysis for nearest-neighbor gene sets for each of the clusters. Genes counts for each cluster are displayed below their group identifier.