Figure 7.

APOE4 effects on astrocyte transcriptome. (A) Bar charts reporting the number of DEGs encoding for proteins with known function in each functional class, as exclusively identified in astrocytes (n = 234 DEGs) of 9–12- vs. 2–3-mo-old E4F mice only, but not in 9–12- vs. 2–3-mo-old E3F mice. (B and C) Representative confocal images of GFAP⁺ astrocytes in the cortex of 9-mo-old E3F and E4F mice (B; scale bar = 50 µm) and quantification of GFAP⁺ cortical astrocytes in 2–3- and 9–12-mo-old E3F and E4F mice (C). Mean ± SEM, n = 5 mice per group. Significance by one-way ANOVA followed by Bonferroni post hoc test.