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. Author manuscript; available in PMC: 2022 Oct 6.
Published in final edited form as: Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795

Figure 5. P2Y14 promotes toxic and biliary liver fibrosis.

Figure 5.

A-C. Liver fibrosis and injury were determined by analysis of the Picrosirius Red area, hepatic hydroxyproline content, and serum ALT in (A) WT (n=7) and P2Y14-knockout (n=7) mice treated with 6 injections of CCl4 (0.5 ml/kg), (B) in male and female Mdr2ko mice (n=22), and P2Y14/Mdr2 double knockout mice (n=21) or in (C) WT (n=10) and P2Y14-knockout (n=9) mice that underwent bile duct ligation (BDL) for 16 days. Data are shown as means ± SEM. Scale bar 200 μm.