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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Int J Obes (Lond). 2016 Apr 14;40(8):1301–1309. doi: 10.1038/ijo.2016.53

Table 2.

67 SNPs individually associated with BMI

Variant # In or nearest gene (distance) Alleles risk/non-risk Allele frequency risk allele Increase of maximum BMI (kg m−2) per risk allele P-value, maximum BMI N, childhood Rate of BMI change/year R/R to NR/NR in childhood P-value, childhood BMI increase/year N, adulthood Rate of BMI change/year R/R to NR/NR in adulthood P-value, adulthood BMI increase/year
rs2253629* HEATR5B (intron) C/A 0.94 1.97 1.10E − 06 3365 1.22 vs 1.06 3.70E − 05 2626 0.43 vs 0.33 0.14
rs1511345* ARRDC3 (79 kb) A/G 0.40 0.81 7.93E − 04 3384 1.30 vs 1.15 7.03E − 05 2662 0.47 vs 0.39 0.10
rs8035859* TARSL2 (intron) C/A 0.24 0.38 1.47E − 04 3426 1.27 vs 1.16 9.86E − 05 2691 0.39 vs 0.39 0.72
rs7193144* FTO (intron) C/T 0.14 0.84 6.06E − 05 3410 1.48 vs 1.18 1.62E − 04 2643 0.64 vs 0.41 0.28
rs9294476* MAP3K7 (455 kb) T/C 0.91 0.51 2.27E − 04 3385 1.22 vs 1.13 5.62E − 04 2642 0.45 vs 0.41 0.86
rs4650065* CTH (119 kb) C/T 0.94 2.56 3.06E − 04 3402 1.22 vs 1.16 5.79E − 04 2643 0.42 vs 0.33 0.52
rs4811346* ZFP64 (215 kb) C/A 0.19 0.59 3.91E − 05 3477 1.41 vs 1.17 1.42E − 03 2708 0.42 vs 0.40 0.59
rs1665163* LRP1B (88 kb) A/T 0.62 0.90 4.32E − 04 3191 1.23 vs 1.10 3.15E − 03 2406 0.41 vs 0.38 0.88
rs4715352* GSTA5 (intron) C/T 0.32 0.05 7.73E − 05 3364 1.23 vs 1.16 5.48E − 03 2666 0.43 vs 0.42 0.72
rs13280614* FAM135B (intron) A/G 0.42 0.88 5.96E − 04 3383 1.26 vs 1.16 5.74E − 03 2649 0.43 vs 0.40 0.52
rs2418750* SORCS3 (intron) A/C 0.85 1.18 1.17E − 04 3409 1.21 vs 1.09 7.06E − 03 2675 0.47 vs 0.42 0.59
rs17545090* ONECUT (324 kb) G/T 0.76 0.76 8.41E − 04 3357 1.22 vs 1.15 7.12E − 03 2656 0.42 vs 0.34 0.05
rs3734353* SIM1 (intron) C/A 0.62 1.07 1.84E − 04 3330 1.24 vs 1.15 7.49E − 03 2581 0.44 vs 0.40 0.35
rs62126199* ZNF419 (exon) G/A 0.18 0.36 6.30E − 04 3420 1.38 vs 1.18 7.78E − 03 2679 0.56 vs 0.40 0.06
rs10503423* FAM167A (intron) C/G 0.63 0.81 9.06E − 04 3408 1.23 vs 1.14 7.85E − 03 2642 0.46 vs 0.33 1.73E − 03
rs16858223* KYNU (intron) G/A 0.85 0.51 4.49E − 04 3450 1.21 vs 1.12 9.28E − 03 2702 0.46 vs 0.40 0.41
rs6459353* CD83 (291 kb) T/C 0.36 0.58 1.03E − 04 3390 1.25 vs 1.17 0.01 2648 0.41 vs 0.38 0.93
rs12882548* NOVA1 (200 kb) G/A 0.14 0.35 1.03E − 06 3390 1.28 vs 1.18 0.01 2654 0.41 vs 0.32 0.68
rs112662024* LPGAT1 (exon) -/G 0.78 0.48 8.02E − 05 3308 1.22 vs 1.19 0.01 2557 0.42 vs 0.35 0.89
rs6712499* CDC42EP3 (120 kb) C/G 0.76 0.94 1.10E − 04 3415 1.21 vs 1.10 0.01 2690 0.43 vs 0.39 0.62
rs9295592* NRSN1 (608 kb) T/C 0.69 1.21 2.92E − 06 3287 1.23 vs 1.11 0.02 2547 0.45 vs 0.43 0.33
rs7238987* CYB5A (exon) T/C 0.32 1.29 6.22E − 07 3413 1.25 vs 1.17 0.02 2643 0.40 vs 0.40 0.89
rs7237384* ZNF532 (intron) C/T 0.87 1.25 1.91E − 04 3386 1.21 vs 1.10 0.02 2686 0.51 vs 0.41 0.85
rs4498447*ǂ CREB5 (intron) T/C 0.80 1.52 4.40E − 04 3217 1.21 vs 1.07 0.02 2525 0.43 vs 0.27 3.70E − 03
rs16829505* RBM43 (142 kb) A/G 0.76 0.57 9.15E − 05 3369 1.22 vs 1.21 0.02 2632 0.42 vs 0.34 0.11
RNF10-R151H* RNF1 (exon) C/T 0.97 1.56 7.20E − 04 3384 1.20 vs 1.12 0.02 2641 0.41 vs 0.21 0.32
rs10048253* ZNF521 (10 kb) C/T 0.90 2.16 7.38E − 04 3434 1.22 vs 1.04 0.02 2699 0.43 vs 0.22 0.01
rs12475149* MAP2 (44 kb) G/T 0.17 1.46 2.97E − 04 3293 1.22 vs 1.13 0.03 2588 0.40 vs 0.37 0.26
rs913257* GORAB (exon) A/G 0.87 1.47 2.65E − 04 3449 1.21 vs 1.10 0.04 2699 0.43 vs 0.40 0.38
rs12617045* GALNT13 (35 kb) G/A 0.71 0.99 4.53E − 04 3368 1.22 vs 1.19 0.04 2636 0.43 vs 0.41 0.49
rs6491241*ǂ ATP5EP2 (4 kb) G/S 0.90 1.84 7.59E − 04 3318 1.21 vs 0.98 0.04 2606 0.44 vs 0.28 7.07E − 03
rs11120137* PFKFB2 (intron) T/C 0.12 0.23 6.83E − 04 3379 1.28 vs 1.19 0.04 2638 0.42 vs 0.28 0.30
rs2565611* EDEM1 (263 kb) T/C 0.40 0.48 1.21E − 04 3311 1.23 vs 1.17 0.04 2558 0.42 vs 0.38 0.35
rs7278294* DSCAM (intron) C/T 0.49 0.77 1.48E − 04 3308 1.25 vs 1.17 0.04 2607 0.41 vs 0.39 0.92
rs251369* PCDHA (intron) A/T 0.52 0.80 7.84E − 05 3364 1.22 vs 1.15 <0.05 2611 0.40 vs 0.40 0.64
rs2894545* LOC101929683 (6 kb) A/G 0.28 0.68 3.25E − 05 3364 1.23 vs 1.19 <0.05 2646 0.41 vs 0.40 0.66
rs6727677ǂ TGFBRAP1 (intron) G/A 0.35 1.13 1.59E − 04 3354 1.22 vs 1.16 0.05 2634 0.51 vs 0.38 0.02
rs2670134 TMEM14A (10 kb) A/G 0.33 0.43 3.63E − 04 3351 1.22 vs 1.18 0.05 2627 0.42 vs 0.42 0.82
rs2712964 LOC151760 (503 kb) G/A 0.88 1.08 4.33E − 05 3317 1.21 vs 0.90 0.06 2632 0.42 vs 0.17 0.07
rs2283228 KCNQ1 (intron) C/A 0.50 1.11 1.48E − 04 3296 1.21 vs 1.15 0.06 2564 0.45 vs 0.40 0.08
13:33860035 STARD13 (o1 kb) C/A 0.98 4.68 1.43E − 04 3428 1.20 vs 1.08 0.08 2689 0.42 vs 0.32 0.05
rs1888687 NRP1 (intron) C/G 0.14 0.68 3.46E − 04 3419 1.22 vs 1.18 0.08 2668 0.43 vs 0.42 0.50
rs10792857 ME3 (intron) A/G 0.34 0.50 8.14E − 04 3404 1.26 vs 1.18 0.09 2669 0.45 vs 0.40 0.21
rs1418029 STK35 (22 kb) G/A 0.12 0.44 3.28E − 04 3252 1.36 vs 1.19 0.09 2563 0.42 vs 0.32 0.95
rs62097832 MC4R (46 kb) G/A 0.58 1.11 1.00E − 04 3363 1.23 vs 1.19 0.12 2657 0.45 vs 0.38 0.16
rs11652094 MAP2K3 (16 kb) G/C 0.73 1.48 1.37E − 05 3423 1.21 vs 1.16 0.12 2677 0.45 vs 0.39 0.10
rs193226243 GCK (o1 kb) A/G 0.09 0.12 7.12E − 04 3413 1.39 vs 1.19 0.16 2680 0.42 vs 0.41 0.80
rs1334241 FOXO1A (intron) A/G 0.43 0.91 3.12E − 05 3396 1.22 vs 1.17 0.16 2646 0.41 vs 0.40 0.62
rs7944983 DUSP8 (3 kb) T/C 0.12 2.07 3.29E − 05 3417 1.29 vs 1.19 0.16 2689 0.41 vs 0.41 0.56
rs680959 UBE2E2 (212 kb) G/C 0.52 0.74 3.69E − 05 3334 1.22 vs 1.66 0.16 2610 0.44 vs 0.41 0.50
rs718484 CADM1 (42 kb) A/G 0.28 0.85 6.16E − 05 3423 1.22 vs 1.18 0.17 2659 0.43 vs 0.41 0.36
rs1903235ǂ NELL1 (27 kb) A/G 0.25 0.53 9.46E − 04 3200 1.25 vs 1.19 0.17 2498 0.48 vs 0.39 0.01
rs4673905 SPATS2L (7 kb) A/G 0.79 1.07 5.85E − 05 3354 1.21 vs 1.15 0.20 2585 0.42 vs 0.38 0.95
rs4968014 GGA2 (2 kb) A/C 0.78 0.81 2.66E − 04 3354 1.20 vs 1.16 0.24 2629 0.47 vs 0.42 0.43
rs9381282ǂ C6orf223 (35 kb) A/C 0.54 1.05 2.91E − 04 3468 1.19 vs 1.15 0.24 2702 0.47 vs 0.36 4.96E − 03
rs6656451 LEPR (intron) C/T 0.73 0.77 1.12E − 04 3323 1.21 vs 1.17 0.24 2598 0.43 vs 0.42 0.64
rs12216336ǂ HLA-DOA (4 kb) G/C 0.13 1.79 9.66E − 05 3232 1.31 vs 1.20 0.39 2533 0.44 vs 0.24 9.64E − 03
rs12123938 KAZN (intron) A/G 0.92 1.20 6.31E − 04 3251 1.20 vs 1.05 0.41 2577 0.44 vs 0.42 0.55
rs6555834 SLIT3 (intron) T/C 0.82 0.79 7.88E − 04 3404 1.21 vs 1.18 0.42 2627 0.43 vs 0.42 0.21
rs354720 ARHGAP15 (intron) G/C 0.87 1.35 5.39E − 05 3323 1.19 vs 1.11 0.50 2578 0.51 vs 0.41 0.19
rs6740224 STAM2 (1 kb) C/A 0.57 0.87 3.99E − 05 3444 1.22 vs 1.20 0.52 2698 0.42 vs 0.36 0.19
rs618823 ZDHHC14 (intron) C/T 0.61 0.66 5.62E − 05 3396 1.21 vs 1.19 0.56 2680 0.41 vs 0.39 0.71
rs6578563 OR51V1 (21 kb) T/A 0.77 1.08 2.88E − 04 3378 1.22 vs 1.21 0.69 2645 0.43 vs 0.38 0.16
rs6548238 TMEM18 (33 kb) C/T 0.85 0.17 4.10E − 05 3395 1.28 vs 1.20 0.71 2632 0.42 vs 0.31 0.36
rs7903146ǂ TCF7L2 (intron) T/C 0.08 2.37 3.28E − 04 3294 1.25 vs 1.20 0.86 2508 0.43 vs 0.27 0.01
rs1930503 C9orf123 (21 kb) A/G 0.60 0.82 6.87E − 04 3410 1.19 vs 1.18 0.94 2679 0.44 vs 0.33 0.22
rs4803607 CD177 (33 kb) A/T 0.31 1.35 5.93E − 04 3351 1.21 vs 1.17 0.99 2617 0.45 vs 0.41 0.29

Abbreviations: BMI, body mass index; NR, non-risk allele; R, risk allele; SNP, single-nucleotide polymorphism. P-value maximum BMI indicates P-value for association with maximum BMI measured from any longitudinal exam when the subject was ⩾age 15 years and oral glucose tolerance test results confirmed that the subject did not have diabetes (N=5918). N, childhood/adulthood indicates number of subjects with at least two visits 24 months apart in childhood or adulthood, respectively.

*/ǂ

indicates significant results (P<0.05) for associations with rate of BMI change in childhood or adulthood, respectively. Significant differences are shown in bold. Difference in the rate of BMI change (adjusted for sex, estimate of European admixture, date of birth as covariates and sibling relationships) between homozygous risk allele carriers and homozygous non-risk allele carriers.