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. 2022 Sep 1;17(9):e0271950. doi: 10.1371/journal.pone.0271950

Fig 4. CSE treated RPE cell injection increased retinal folds, retinal detachment and PVR membranes thickness compared to control RPE.

Fig 4

Fundus imaging, OCT, and histology of representative eyes from mice injected intravitreally with control RPE cells (A,B,C) vs. RPE cells treated and resuspended with 0.5% CSE (D,E,F). All images were taken at 4 weeks post-RPE injection. Intravitreal injection of CSE-treated RPE resulted in development of more severe PVR by 4 weeks with evidence of retinal folding, significant areas of detachment, and inflammatory infiltrate. The inflammatory infiltrate is especially prevalent in the vitreous of the top section in F. Arrows and * in E and F highlight retinal folds observed on OCT imaging seen in histologic cross-sections. Scale bars represent 100 microns (μm) in length.