Table 3.

Proposed inclusion criteria for neonatal multisystem inflammatory syndrome (MIS-N) secondary to maternal SARS-CoV-2 exposure or infection.

(1) A neonate aged <28 days at the time of presentation

(2) Laboratory or epidemiologic evidence of SARS-CoV-2 infection in the mother

• Positive SARS-CoV-2 testing by RT-PCR, serology (IgG or IgM—and not secondary to immunization), or antigen during pregnancy OR • Symptoms consistent with SARS-CoV-2 infection during pregnancy OR • COVID-19 exposure during pregnancy with a confirmed case of SARS-CoV-2 infection • Serological evidence (positive IgG specific to SARS-CoV-2 but not IgM) in the neonate (and not secondary to maternal immunization)

(3) Clinical criteria

• Meet clinical criteria in Table 1 (except for fever)

(4) Laboratory evidence of inflammation

• Meet inflammatory marker criteria listed in Table 1

(5) No alternative diagnosis (viral or bacterial sepsis; birth asphyxia; maternal lupus etc.) that can explain the clinical features

Modified from Pawar et al.¹¹