Comparison 1. Pneumococcal vaccine versus control vaccine.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Neonatal infection	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Pneumonia	1	149	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.18, 1.90]
1.2 Meningitis	1	149	Risk Ratio (M‐H, Fixed, 95% CI)	3.04 [0.13, 73.44]
1.3 Otitis media	1	149	Risk Ratio (M‐H, Fixed, 95% CI)	0.14 [0.01, 2.75]
1.4 All infections	2	241	Risk Ratio (M‐H, Fixed, 95% CI)	0.66 [0.30, 1.46]
2 Pneumococcal colonization	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 At 2‐3 months of age	2	146	Risk Ratio (M‐H, Random, 95% CI)	1.13 [0.46, 2.78]
2.2 By 6‐7 months of age	2	148	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.22, 2.08]
2.3 By 16 months of age	1	56	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.11, 0.98]
2.4 Serotype 6	1	92	Risk Ratio (M‐H, Random, 95% CI)	0.12 [0.01, 2.09]
2.5 Serotype 14	1	92	Risk Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
2.6 Serotype 19	1	92	Risk Ratio (M‐H, Random, 95% CI)	2.09 [0.40, 10.85]
3 Neonatal antibody levels at birth			Other data	No numeric data
3.1 Serotype 6			Other data	No numeric data
3.2 Serotype 14			Other data	No numeric data
3.3 Serotype 19			Other data	No numeric data
4 Maternal antibody levels post vaccination			Other data	No numeric data
4.1 Serotype 6			Other data	No numeric data
4.2 Serotype 14			Other data	No numeric data
4.3 Serotype 19			Other data	No numeric data
5 Percentage of mothers with seroprotection	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Serotype 6 at delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	1.49 [1.31, 1.69]
5.2 Serotype 14 at delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	1.40 [1.25, 1.56]
5.3 Serotype 19 at delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	2.29 [1.89, 2.76]
5.4 Serotype 6 at 12 months post‐delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [1.00, 1.12]
5.5 Serotype 14 at 12 months post‐delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.98, 1.15]
5.6 Serotype 19 at 12 months post‐delivery	1	340	Risk Ratio (M‐H, Fixed, 95% CI)	1.59 [1.37, 1.85]
6 Adverse maternal effects	2		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
6.1 Tenderness at the injection site	2	130	Risk Ratio (M‐H, Random, 95% CI)	3.20 [0.32, 31.54]