Lopes 2009.

Methods	Pregnant women were randomly assigned to one of three groups for the study.
Participants	Country: Brazil. Number: 47 women in the control group (no vaccine); 45 women received vaccine at 30‐34 weeks of gestation; and 47 women received vaccine after delivery. Mean age: data not available. Mean gestational age: data not available.
Interventions	23‐valent pneumococcal polysaccharide vaccine.
Outcomes	Incidence of neonatal infection. Incidence of infant pneumococcal colonization. Maternal antibody levels (GM).
Notes	Data from women received vaccine after delivery were excluded from analysis.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Details were not reported.
Allocation concealment (selection bias)	Unclear risk	Details were not reported.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Lack of blinding would be unlikely to affect results.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Lack of blinding would be unlikely to affect results.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All infants completed follow‐up at 3 months old.
Selective reporting (reporting bias)	Low risk	All outcomes were predefined and reported.
Other bias	Low risk	The trial appears to be free of industry sponsorship.