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. 2022 Aug 24;119(35):e2121985119. doi: 10.1073/pnas.2121985119

Fig. 1.

Fig. 1.

Optimal transport of an active drop. A schematic illustrating our framework to solve the problem of transporting an active drop by minimizing a specified cost function, such as the mechanical work. The spatiotemporal profile of activity ζ(x,t) is the control variable, and the transport task involves moving the drop from position X0 and size R0 to a final position XT and size RT in a finite time T. We employ two complementary approaches: 1) finite-dimensional optimal control using Pontryagin’s maximum principle on an ODE-based reduced order model that captures parametrized features of the drop; and 2) constrained numerical optimization of the nonlinear continuum PDE using a gradient-free evolutionary algorithm, such as CMA-ES (see PDE Control main text).