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. 2022 Aug 24;119(35):e2121985119. doi: 10.1073/pnas.2121985119

Fig. 3.

Fig. 3.

ODE optimal control. (A and B) Sample trajectories for the globally optimal mean (ζ0) and gradient (Δζ) activity are shown in A, and the associated controlled dynamics for the drop position (X) and size (R) are shown in B. The parameters chosen are XT=0.8,R0=6, RT = 3, T = 1, and η=0.1. Note that as η sets a time scale, only the ratio T/η is important. For these parameter values, we see that the size change is nonmonotonic, which is reflected in the sign change in the mean activity ζ0(t). The initial contractile activity (ζ0>0) causes the drop to shrink and consequently accelerate its translation, and, later, the activity switches over to become extensile (ζ0<0) to allow the drop to reach its larger final size RT. (C) The phase diagram here represents the feasibility region for optimal transport of a parabolic active drop, as a function of the nondimensionalized drop displacement (XT/R0) and its size disparity (RT/R0). The black curve is the maximum achievable displacement XT for a given relative change in size (RT/R0), beyond which no smooth optimal controls exist. Below the black curve is the feasible region, with the shaded color representing the total work done [nondimensionalized as WT/(ηR04)] by the globally optimal policy, with the cost increasing from blue to red. The blue curves in the shaded region demarcate the parameter space where the global optimizer has a monotonic or nonmonotonic size dependence as a function of time. Nonmonotonic changes in size are favored in the region bordered by the blue and black curves and only occur when RT>R0. For RT<R0, the optimal policies have a monotonic size dependence. The black dot corresponds to the solution shown in A and B.