Fig. 5.

Metabolic signatures and essential genes as potential drug targets. (A) UpSet plot of comparison combinations in each group. Each row corresponds to a condition, and each bar shows a different combination. The filled-in cells show which condition is part of an intersection, and the lines connecting the filled-in cells show in which direction the plot should be read. TM-specific reactions are colored maroon, and common reactions between breast-TPs and TNBC-TMs are colored pink. (B) Genes predicted to be essential for biomass production are colored blue in each condition. Among the essential genes, those that are not essential in most healthy models can be considered potential drug targets for cancer therapy. ACC, adrenocortical carcinoma; Ad, adenocarcinoma; AdrenalG., adrenal gland; amyg., amygdala; basalG, basal ganglia; BRCA represents breast invasive carcinoma; hipp., hippocampus; HT, healthy tissue; hypo., hypothalamus; PCPG, pheochromocytoma and paraganglioma; Sc, squamous cell carcinoma; substantiaN, substantia nigra.