. Author manuscript; available in PMC: 2023 Sep 1.

Published in final edited form as: Clin Pharmacol Ther. 2022 Jun 22;112(3):573–592. doi: 10.1002/cpt.2670

Table 3:

Summary of the DDI predictions of P-gp inhibitors using total or unbound C_max divided by geometric mean of IC₅₀ or K_i values towards P-gp.

	Total records	TN	TP	FN	FP	Sensitivity	Specificity	PPE	NPE
total C_max/IC₅₀ (0.1 as cut-off)	57	15	23	2	17	92%	47%	43%	12%
unbound C_max/IC₅₀ (0.02 as cut-off)	57	25	19	6	7	76%	78%	27%	19%

TN: true negative; TP: true positive; FN: false negative; FP: false positive; Sensitivity: TP/(TP + FN), proportion of actual positive DDIs that were predicted as such; Specificity: TN/(TN+ FP), proportion of actual negative or no DDI risks that were predicted as such; PPE: positive predictive error, FP/(FP + TP), proportion of studies that were conducted that actually did not need to be (no DDI risk); NPE: negative predictive error, FN/(FN+ TN), proportion of studies that were predicted as no risk but actually demonstrated DDI risk.