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. 2022 Aug 25;2022:3096528. doi: 10.1155/2022/3096528

Figure 1.

Figure 1

Severe asthma was associated with higher estrogen, and reduced androgen levels showing sex hormones fluctuation status correlates with asthma prevalence and remission. Severe asthma is mediated by Th17 cells, and estrogen is involved in the differentiation of Th17 cells along with its cytokines, whereas androgen reduces allergic inflammation and IL-17A protein expression. To know the concentration of sex hormones in severe asthma, we collected blood samples from different asthma groups and processed them for flow enzyme-linked immunosorbent assay (ELISA) to measure DHT, E2, and DHT/E2 ratio. Subjects were diagnosed according to GINA guidelines and mild and moderate asthma were labeled as “asthma” to separate from severe asthma. (a) Measurement of DHT. (b) Measurement of E2. (c) Measurement of DHT/E2 ratio. DHT-dihydrotestosterone as androgen, E2-17β-estradiol as estrogen, and DHT/E2-androgen estrogen ratio. From here onwards (in this section), DHT as androgen and E2 as estrogen have been used frequently and interchangeably. (∗p < 0.05).