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. 2022 Aug 25;2022:2633123. doi: 10.1155/2022/2633123

Figure 8.

Figure 8

The effect of S100A12 knockdown on inflammation and oxidative stress in OGD model. (a) CCK-8 assay was used to gauge AC16 cell viability in Con+Si-NC, Con+Si-S100A12, OGD+Si-NC, and OGD+Si-S100A12 groups (n = 3, per group). (b and c) The protein expression level of S100A12 in the above four groups (n = 3, per group). (d) The level of TNF-α in the above four groups (n = 3, per group). (e) The level of IL-1β in the above four groups (n = 3, per group). (f) The level of MDA in the above four groups (n = 3, per group). (g) The ROS production was detected by the DCFH-DA in the above four groups (n = 3, per group) (magnification ×400, scale bar = 200 μm). Data were presented as mean ± SD based on at least three independent experiments. Notes: S100A12: S100 calcium-binding protein A12; OGD: oxygen-glucose deprivation; Con: control; Si: small interfering; SD: standard deviation; DCFH-DA: dichlorodihydrofluorescein diacetate. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.