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. 2022 Aug 25;2022:9148257. doi: 10.1155/2022/9148257

Figure 6.

Figure 6

α-KG could reduce neuronal apoptosis by inhibiting IR. (a) Level of p-IRS1 (Ser636/639), IRS1, p-IRS1 (Ser636/639)/IRS1 ratio, and p-S6K1 (Thr389) in control, Con+PA, SAH, SAH+DMKG, and SAH+DMKG+PA groups (one-way ANOVA, F = 10.82; F = 10.76; F = 17.02; F = 15.73). (b) The ratio of GLUT4 expression in plasma membrane to total levels of GLUT4 expression in control, Con+PA, SAH, SAH+DMKG, and SAH+DMKG+PA groups (one-way ANOVA, F = 72.93). (c) Glucose uptake ability was calculated by the average fluorescent intensity of 2-NBDG in the control, Con+PA, SAH, SAH+DMKG, and SAH+DMKG+PA groups, bar = 200 μm (Kruskal-Wallis). (d) Expression of cleaved caspase-3 in the control, Con+PA, SAH, SAH+DMKG, and SAH+DMKG+PA groups (one-way ANOVA, F = 9.52). (e) Proportion of early apoptotic detected by Annexin V-FITC/PI staining (one-way ANOVA, F = 39.1) (∗P < 0.05, ∗∗P < 0.01).