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(a) The binding mode of alpha-ketoglutarate to S6K1 protein was obtained based on docking. The left picture is the overall view, and the right picture is the local view. Blue stick is the small ligand molecule, light blue cartoon is the protein, gray dotted line represents hydrophobicity, and yellow dotted line represents hydrogen bonding. (b) The ability of α-KG to inhibit S6K1 activity was assayed by ADP-Glo™ kinase kit (one-way ANOVA, F = 553.81) (∗∗P < 0.01).
